摘要
目的 了解经不同剂量60 Co辐照血红细胞、白细胞 (嗜中性粒细胞、嗜碱性粒细胞、嗜酸性粒细胞、淋巴细胞与单核细胞 )、血小板超微结构的变化。方法 应用透射电子显微镜观察细胞形态。结果 经不同剂量60 Co辐照后血液部分嗜中性粒细胞与淋巴细胞 ,出现细胞超微结构异常与细胞凋亡现象 ,占有核细胞的 7%～ 2 4 %。且随着辐照剂量的增加 ,嗜中性粒细胞与淋巴细胞超微结构发生异常与凋亡比例也有所增加。未发现嗜碱性粒细胞、嗜酸性粒细胞、单核细胞、血小板与红细胞超微结构的异常。结论 经 1 5～ 35GY60 Co辐照后血液除部分嗜中性粒细胞与淋巴细胞超微结构有影响外 。
Objective To understand the understand the ultrastructural changes of blood cells irradiated by different doses of 60 Co,including red blood cells,leukocyte(neutrophils,basophils,eosinophils,lymphocytes and monocytes)and platelet.Method Using transmission electron microscopy to observe the blood cells morphology.Result After irradiation,some neutrophils and lymphocytes showed ultrastructure changes of abnormal cellular structure and apoptosis,accounting for 7%～24% of total nucleated cells.The percentages of abnormal cells and apoptosis incereased with incerasing irradiation doses.No abnormalities were observed in basophils,eosinophils,monocytes,platelets,and red blood cells.Conclusion 15～35Gy 60 Co irradiation influenced the ultrastructure of neutrophils and lymphocyte,but the other cells were not influenced.
出处
《中国输血杂志》
CAS
CSCD
2004年第3期143-146,共4页
Chinese Journal of Blood Transfusion
基金
上海市卫生局研究课题项目 (编号 0 3 40 5 4)
