摘要
目的 探讨原发性高血压 (EH)伴自主神经病变 (ANP)患者的心率变异性 (HRV)特点 ,评价HRV对此类患者的诊断价值。方法 选取 5 0例原发性高血压患者分两组 :1级EH组 2 6人 ,2级EH组 2 4人 ,对照组 36人。所有受检者均接受心血管反射试验 (CVR)检查和HRV分析 ,并且绘制NN间期散点图。结果 经HRV分析和心血管反射试验检查 ,EH患者的自主神经病变检出率分别为 4 8 0 0 %和 2 6 0 0 %。与对照组比较 ,各EH组的HRV时域指标和频域指标均显著降低 (P <0 0 5 ) ,彗星状散点图比例显著下降 (P <0 0 5 ) ,鱼雷状散点图增多。上述情况 2级EH组较 1级EH组更为显著 (P <0 0 5 )。HRV分析和心血管反射试验之间存在着较强的相关性。结论 HRV分析是早期发现EH伴自主神经病变的灵敏方法。老年EH患者的自主神经病以迷走神经病变为主。
Objective To study the characteristics of heart rate variability(HRV) in the patients with essential hypertension(EH) and autonomic neuropathy(ANP)and to evaluate the diagnostic value of HRV in EH patients with ANP.Methods 50 EH patients were divided into two groups:26 of grade-l group, 24 of grade-2 group, and 36 age-and sex-matched normal people were chosen as the controls. HRV and cardiovascular reflex tests(CVR) were performed in all people. In addition, the points of NN Intervals were achieved.Results The overall frequency of ANP in EH patients respectively was 48.00% by HRV and 26.00% by CVR (P<0.05). Compared with the control,the HRV idexes of time domain and frequency domain significantly decreased in EH groups(P<0.05), which in grade-2 EH group were significantly decreased than those in grade-1 EH group(P<0.05). As the patterns of NN Interval plots were concerned, the proportion of comet-shaped pattern plots in EH groups significantly decreased while the proportion of torpedo-shaped pattern plots increased. There was a strong relationship between HRV and CVR.Conclusion HRV can be used as a sensitive method to diagnosis ANP in EH patients of early state and vagal neuropathy is the majority of the ANP in old EH patients.
出处
《中国实验诊断学》
2004年第3期271-273,共3页
Chinese Journal of Laboratory Diagnosis
关键词
原发性高血压
自主神经病变
心率变异性
essential hypertension
autonomic neuropathy
heart rate variability
