摘要
用4种酸性粘蛋白组织化学染色法,观察90例卵巢良性和恶性粘渡性囊腺瘤酸性粘蛋白的含量和成分。发现粘液性囊腺癌酸性粘蛋白含量明显高于交界性粘液性囊腺瘤和钻液性囊腺瘤。绝大多数粘液性囊腺瘤酸性粘蛋白的主要成分是唾液酸粘蛋白,或唾液酸和硫酸两种粘蛋白的混合,仅少数瘤含有较多硫酸粘蛋白。与囊腺癌上皮比较,良性囊腺瘤上皮中唾液酸粘蛋白含量增多,或两种酸性粘蛋白均减少。据认为:①当囊腺瘤恶变时,酸性粘蛋白逐渐增加;②唾液酸粘蛋白(部分肿瘤含硫酸粘蛋白)增多是卵巢粘液性囊腺癌的组化特点;③酸性粘蛋白含量可能与肿瘤生物学行为有关。
Four staining methods were used for the identification of thecomposition & quantity of acidic mucoproteins (sialic & sulfuricmucoproteins) in benign & malignant mucinous cystadenoma ofovary. It was found that mucinous cystadenocarcinoma containd muchmore acidic mucoprotein than that of mucinous cystadenoma &borderline mucinous cystadenoma. Compared with adenomatous epith-elium under malignant change, the content of sialic mucoprotein inbenign adenomatous epithelium was increased or both mucoproteinsdecreased. These data suggest ed that during malignant change of ovar-ian cystadenoma, the quantity of acidic mucoproteins would increasegradually. Increase of the quantity of sialic mucoprotein (mixedwith sulfuric mucoprotein in some tumors) is histochemicallycharacteristic in mucinous cystadenocarcinoma, of the ovary. Theremay be a relationship between the quantity of acidic mucoproteins& biological behavior of the ovarian mucinous cystadenocarcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1989年第2期65-67,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
卵巢囊腺瘤
酸性粘蛋白
组化改变
ovarian cystadenoma
malignant change
acidic mucoproteins histochemical change
