摘要
报告138例肾穿刺活检狼疮性肾炎(LN)的病理变化,并讨论其病理诊断、分型及临床病理联系。138例中系膜增生型23例,局灶增生型14例,弥漫增生型72例,膜型25例,硬化型4例,以下病变提示LN:①肾小球病变多样性,②肾小管萎缩、间质炎症和(或)局部有免疫复合物形成,③电镜下见内皮下、基膜内、上皮下、系膜区广泛电子致密物沉积。苏木素小体具诊断意义,其阳性率为18.8%。肾组织局部HBsAg阳性率达57.8%.文章讨论了HBV感染和SLE发病的关系。
The pathologic changes & clinicopathologic relationships of 138renal biopsies of lupus nephritis(LN) were observed. The caseswere grouped into different types according to the pathologic class-ification of WHO of LN in 1982. They were mesangial proliferativeLN (WHO class Ⅱ) 23 cases, focal segmental proliferative LN(WHOclass Ⅲ) 14 cases, diffuse proliferative LN (WHO class Ⅳ) 72cases, membranous LN (WHO class Ⅴ) 25 cases & glomerularsclerosis (WHO class Ⅵ) 4 cases, some clinical manifestationswere correlated with particular pathologic changes. However, nocharacteristically specific lesions of LN was found. The only dia-gnostic feature in LN is the appearance of the hematoxylin bodies,which was presented in 23.2% in this series. The followingpathologic changes were considered to be related with LN: (1) Va-rious pathologic changes appeared simultaneously in different glomer-uli, lobuli & loops in the same patient. (2) Obvious tubular at-rophy & interstitial inflammation with or without immune complexesdeposits locally. (3) Electron dense deposits diffusely distributedin all portions of glomeruli. HBsAg was detected in situ of glomeruliin 57.8% of cases. The possible relationship between HBV infection& the occurence of LN was discussed.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1989年第1期1-4,共4页
Chinese Journal of Clinical and Experimental Pathology
