摘要
目的 :探讨高脂饮食对肥胖倾向 (OP)和肥胖抵抗 (OR)大鼠血脂和肿瘤坏死因子α(TNF α)水平的影响。方法 :将雄性SD大鼠随机分成对照组和高脂组 ,分别用普通饲料和高脂饲料饲养 14周 (高脂组大鼠根据体重增加程度分成肥胖倾向和肥胖抵抗两组 ) ,分别检测实验前、实验开始后第 3周末、第 14周末的血清总胆固醇(TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)和TNF α水平。结果 :给予高脂饲料 3周后 ,OP组TG、TC水平显著高于OR组和对照组 (P <0 .0 5 ) ,HDL C水平显著低于对照组 (P <0 .0 5 )。实验结束时 ,OP组TG、HDL C和TNF α水平与OR组和对照组出现明显差异 (P <0 .0 1) ;OP和OR组TC水平显著高于对照组 (P <0 .0 1) ;OR组TNF α水平显著高于对照组 (P <0 .0 5 )。结论 :高脂饮食可能更易诱发高胆固醇血症而不是高甘油三酯血症 ,并可能通过改变体内TNF α水平来影响肥胖相关合并症的发生。
Objective: To study the influence of high-fat diet on levels of serum lipid and tumor necrosis factor-α (TNF-α) in rats with obesity prone and obesity resistance. Methods: Male Sprague-dawley rats were divided into control group and high-fat group randomly,maintained respectively a standard and a high-fat diet for 14 weeks. Then the rats of high-fat group were divided into 2 groups according to the body weight. The levels of serum total cholesterol(TC),triglyceride(TG),high density lipoprotein-C(HDL-C) and TNF-α were determined at the 1st,3rd,14th week. Results: After 3 weeks,the TC,TG values of OP group were significantly increased compared with OR and control groups( P <0.05),its HDL-C values were significantly decreased compared with control group ( P <0.05). At the end of the experiment,the TG,HDL-C and TNF-α levels of OP group differed from the OR and control groups ( P <0.01),the TC levels of OP and OR groups were significantly increased compared with the control ( P <0.01). The TNF-α levels in OR rats were significantly higher than control rats ( P <0.05). Conclusion: The high-fat diet may induce hypercholesterolemia but not hypertriglyceridemia. It could influence the occurrence of obesity and its complications by changing serum TNF-α levels in rats.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2004年第4期330-332,共3页
Journal of China Medical University
关键词
高脂饮食
肥胖倾向
肥胖抵抗
血脂
肿瘤坏死因子
high-fat diet
obesity prone
obesity resistant
blood lipid
tumor necrosis factor-α
