摘要
给正常家兔静脉注射不同剂量绿脓杆菌活菌(7×10~9、2×10^(10)/kg)造成败血症后,外周血中TNF水平明显升高,其变化特征与内毒素休克并不相同,2×10^(10)/kg组血浆TNF水平显著高于7×10~9/kg组(P<0.01)。输注绿脓杆菌活菌后,与对照组相比,血浆胰高血糖素呈持续升高(P<0.05～0.01),胰岛素和血糖有短暂升高(P<0.05～0.01),血浆乳酸和β-G水平呈持续增高(P<0.05～0.01),上述改变在2×10^(10)/kg组要甚于7×10~9/kg组(P<0.05～0.01),此外2×10^(10)/kg组动物死亡率和MABP的下降较之7×10~9/kg组也更为严重。这些结果表明输注绿脓杆菌活菌后血浆TNF水平的升高与败血症的发生发展以及病变严重程度有密切关系。
It was found that after 2 dosages of Pseudomonas aeruginosa suspension(7×109/kg and 2×1010/kg)were infused to rabbits respectively to induce septicemia,the elevation of the tumor necrosis factor(TNF)level in the circulating blood was higher in 2×1010/kg group than in 7×109/kg group.The dynamic changes of circulation TNF in P.aeruginosa septicemia were different from those in endotoxin shock.There was a continous increase of plasma glucagon,Iactic acid and β-G(P<0.05~0.01)and a transient increase of plasma insulin and glucose(P<0.05~0.01).These changes were more marked in the 2×1010/kg group than in the 7 X lO'/kg groupC P<0.05~0.01).The death rate was higher and the decrease of MABP more severe in the 2×1010/kg group than in the 7×109/kg group.These findings suggest that there may be a correlation between the elevation of TNF level in circulating blood and the severity of the pathological manifestations of P.aeruginosa septicemia.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1993年第2期145-149,共5页
Journal of Third Military Medical University
基金
国家自然科学基金
关键词
败血症
绿脓杆菌
肿瘤坏死因子
septicemia
Pseudomonas aeruginosa
tumor necrosis factor
