摘要
大鼠烫伤后24 h,伴刀豆素A(Con A)诱导的脾淋巴细胞转化及白细胞介素2(IL-2)生成明显降低,内毒素(LPS)诱导的腹腔巨噬细胞产生白细胞介素1(IL-1)量也明显减少。烫伤后72 h,上述免疫学指标达到最低值,120 h仍处于较低的水平。放射免疫测定的结果表明,大鼠烫伤后血浆β-内啡肽(β-EP)含最除伤后2 h稍有升高外,其余各时间点无明显变化。血浆强啡肽A(Dyn A)的含量明显降低,其变化过程与免疫功能的变化基本一致。提示,烫伤后血浆强啡肽A含量降低可能与免疫功能有关。
The immune function of rats was markedly suppressed following burn injury. At 24 h after burn, the lymphoproliferative response to Con A and IL-1 and IL-2 production in burned rats were significantly reduced, as compared with control animals. At 72 h after burn the immune parameters as above were at the lowerest levels. At 120 h after burn, a slight elevation of immune function was observed, but still lower than the levels of controls. The results of radioimmunoassay of β-endorphin and dynorphin A in plasma showed that the concentration of β-endorphin in plasma was not markedly changed after burn except at 2 h after injury, and that of dynorphin A in plasma was reduced markedly after burn injury. The dynamic change of circulating dynorphin A in plasma was coincident with that of immune function. Our results suggest that burn-induced immunosuppression may be related to decrease of circulating dynorphin A levels.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1993年第1期23-26,共4页
Academic Journal of Second Military Medical University
关键词
内啡肽
白细胞介素
烧伤
免疫测定
endorphin
dynorphin
immune response
interleukin
burn
radioimmunoassay
animal
rats
