摘要
应用放射免疫测定方法,观察了大肠癌患者血浆生长抑素免疫活性物质(SLI)含量变化。结果显示,肿瘤组血浆SLI含量显著升高(P<0.01);血浆SLI含量以Dukes A,B期组升高更为明显;手术切除肿瘤后,血浆SLI含量较术前明显降低(P<0.05);血浆SLI含量与肿瘤细胞分化程度、肿瘤部位无关。结果说明,机体生长抑素(SS)的分泌和释放与大肠癌的病理过程密切相关。大肠癌早、中期血浆SS含量升高,可能是机体神经内分泌系统的一种代偿反应,对抑制自身肿瘤细胞生长及扩散具有一定意义。而大肠癌晚期血浆SS含量降低,提示病程进展可能与机体SS分泌不足或下降有关。
The contents of plasma somatostatin-like-immunoreactivity (SLI) were measured by radioimmunoassay in patients with colorectal cancer. The results showed that the content of SLl in cancer group, especially in Dukes A, B patients, was significantly higher than that in contol group (P<0.01), and that the content of SLI was decreased significantly after redical resection of the tumor (P<0.01). This implies that there is a close relationship between secretion and release of somaostatin (SS) and pathophysiology of colorectal cancer, and the increased plasma SS may play a role in inhibition the growth and spread of cancer celis.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1993年第5期451-453,共3页
Academic Journal of Second Military Medical University
关键词
生长抑素
放射免疫测定
大肠肿瘤
colorectal cancer
somatostatin-like-immunoreactivity
plasma
radioimmunoassay
