摘要
作者观察了24例狼疮性肾炎患者、12例正常对照者尿TxA_2、PGI_2代谢产物TXB_2、6-keto-PGF_(1α)含量。结果表明,与正常组相比较,各组狼疮性肾炎患者尿TXB_2含量均增高6-keto-PGF_(1α)含量均降低,TXB_2/6-keto-PGF_(1α)比值均增加,且以肾病组变化最显著。TXB_2/6-keto-PGF_(1α)比值与尿蛋白量呈止相关(r=0.74)。表明狼疮性肾炎患者肾组织内存在严重的TXA_2-PGI_2平衡失调,前列腺素代谢异常可能与狼疮性肾炎的发生、发展有关。检测尿TXB_2/6-keto-PGF_(1α)比值,可作为判断狼疮性肾炎病变程度的指标。
The levels of urine thromboxane B, (TXB2) and 6-keto-PGF1a were measured by radioimmunoassay in 24 patients with lupus nephritis and 12 normal subjects. The results showed that the level of TXB2 and the ratio of TXB2/6- keto- PGF1x in urine were significantly higher, while the level of urine 6-keto-PGF1x( was lower in patients with lupus nephritis than that in normal group. The ratio of TXB2/6-keto-PGF1a in urine was correlated positively to the content of urine protein. These results indicate that there is TXA2-PGI2 imbalance in the kidney in patients with lupus nephritis. TXA2 can play an important pathogenetic role in the progression of lupus nephritis in patients. The ratio of TXB2/6-keto-PGF1x in urine may serve as a parameter in evaluating patients with lupus nephritis.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1993年第5期444-447,共4页
Academic Journal of Second Military Medical University
关键词
狼疮性肾炎
血栓素B2
前列腺素
lupus nephritis
thromboxane B_2
6-keto-PGF1α
urine
patients
human
