急性肝衰竭时脑水肿的发病机制
被引量:2
Pathophysiologic mechanism of brain edema in acute liver failure
摘要
脑水肿是急性肝衰竭晚期常见的致死并发症之一,包括细胞毒性脑水肿和血管源性脑水肿。本文 从高血氨及谷氨酰胺的积聚、缺氧与脑血管扩张、内毒素与细胞因子、星形胶质细胞的肿胀、Na+-K+ATP酶活性降 低等方面阐述急性肝衰竭时脑水肿形成的机制。
参考文献20
-
1Gove CD, Hughes RD, Ede RJ. Regional cerebral edema and chloride space in galactosamine induced liver necrosis in rats. Hepatology, 1997,25(2): 295-301.
-
2Clemmesen JO, Larsen FS, Kondrup J, et al. Cerebral hemiation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology, 1999,23(3): 648-653.
-
3Butterworth RF. Pathophysiology of hepatic encephalopathy: a new look at ammonia. Metab Brain Dis, 2002,17(4): 221-227.
-
4Butterworth RF. Glutamate transporter and receptor function in disorders of ammonia metabolism. Ment Retard Dev Disabil Res Rev, 2001,7(4): 276-279.
-
5Larsen FS, Ejlersen E, Hansen BA, et al. Functional loss of cerebral blood flow autoregulation in patients with fulminant hepatic failure. J Hepatol, 1995,23:212-217.
-
6Cordoba J, Crespin J, Gottstein J, et al. Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis. Gastroenterology, 1999,116:686-693.
-
7Rose C, Michalak A, Pannunzio M, et al. Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology, 2000,31(4):872-877.
-
8李夏青,韩德五.内霉素诱发肝性脑病大鼠脑超微结构观察[J].解剖学杂志,2000,23(5):439-442. 被引量:6
-
9Muto Y, Nouri-Aria KT, Meager A,et al. Enhanced tumor necrosis factor and interleukin-1 in fulminant hepatic failure. Lancet, 1998,9:72-74.
-
10Estrada C, Gomez C, Martin C. Effects of TNF-alpha on the production of vasoactive substances by cerebral endothelial and smooth muscle cells in culture. J Cereb Blood Flow Metab, 1995,15(6):920-928.
二级参考文献7
-
1韩德五 马学惠 等.肝硬化动物模型的研究[J].山西医药杂志,1979,(1):1-1.
-
2韩德五,山西医科杂志,1979年,1期,1页
-
3Ahmed K,Judah JD.Preparation of li-poproteins containing cation-dependentATPase[].Biochimica et Biophysica Acta.1964
-
4.
-
5.
-
6ATPase. Biochimica et Biophysica Acta . 1964
-
7李夏青,韩德五,许瑞龄,赵元昌,马学惠.内毒素诱发肝硬化大鼠发生肝性脑病的实验研究[J].中国病理生理杂志,1999,15(2):151-153. 被引量:26
共引文献9
-
1吕飒,宋红丽,王静艳,刘沛.急性肝坏死小鼠血脑屏障通透性的改变[J].世界华人消化杂志,2004,12(6):1346-1348. 被引量:10
-
2刘洪艳,王静艳,雷薇,闻颖,刘沛.氨对肝硬化大鼠模型脑神经细胞凋亡的影响[J].世界华人消化杂志,2004,12(8):1865-1867. 被引量:9
-
3牛春红,田新强,米亚英.一氧化碳在肝硬化大鼠肝性脑病形成中的作用[J].山西医药杂志,2006,35(9):783-785.
-
4杨继鑫,张振纲,田德英.重型肝炎与肝硬化腹水患者并发低钠血症的研究现状及进展[J].中西医结合肝病杂志,2007,17(1):63-64. 被引量:12
-
5Hui-Ying Zhang,De-Wu Han,Zhong-Fu Zhao,Ming-She Liu,Yan-Jun Wu,Xian-Ming Chen,Cheng Ji.Multiple pathogenic factor-induced complications of cirrhosis in rats: A new model of hepatopulmonary syndrome with intestinal endotoxemia[J].World Journal of Gastroenterology,2007,13(25):3500-3507. 被引量:38
-
6党永岩,叶希韵,申杰.葡萄糖浓度波动对人肝L02细胞损伤的实验研究[J].华东师范大学学报(自然科学版),2010(5):142-148. 被引量:2
-
7王世乾,许德军.血钠水平对重型肝炎患者预后影响的分析[J].国际医药卫生导报,2011,17(6):683-685. 被引量:4
-
8杨树平,王吉耀,贺伯明,方国汀,符荣,陈衔城.一氧化碳与肝硬化大鼠血脑屏障通透性的关系[J].中华肝脏病杂志,2002,10(2):129-131. 被引量:1
-
9陈铿,李平红,李艳玲,杨可立,廖宝林,刘惠媛.乙型肝炎病毒相关慢加急性肝衰竭合并肝性脑病患者临床特点及预后影响因素分析[J].肝脏,2023,28(5):568-571. 被引量:9
同被引文献29
-
1吕飒,宋红丽,王静艳,刘沛.急性肝坏死小鼠血脑屏障通透性的改变[J].世界华人消化杂志,2004,12(6):1346-1348. 被引量:10
-
2廖承德,韩丹,宋光义.高氨血症与急性肝性脑病[J].云南医药,2005,26(2):166-168. 被引量:2
-
3Hong-LiSong SaLu PeiLiu.Tumor necrosis factor-alpha induces apoptosis of enterocytes in mice with fulminant hepatic failure[J].World Journal of Gastroenterology,2005,11(24):3701-3709. 被引量:5
-
4王顺蓉,张英,李著华.血脑屏障的结构与功能研究进展[J].四川生理科学杂志,2005,27(2):88-89. 被引量:17
-
5吕飒,宋红丽,刘沛.肿瘤坏死因子α对急性肝坏死小鼠血脑屏障通透性的影响[J].中华肝脏病杂志,2005,13(11):858-859. 被引量:4
-
6刘曾旭,王航辉,王向东,刘德明.血脑屏障紧密连接的分子构成及信号调控的研究进展[J].江西医学院学报,2006,46(5):173-175. 被引量:6
-
7Vassilios Koussoulas,Michalis Tzivras,Vassiliki Karagianni,Ekaterini Spyridaki,Diamantis Plachouras,Helen Giamarellou,Evangelos J Giamarellos-Bourboulis.Monocytes in systematic inflammatory response syndrome:Differences between sepsis and acute pancreatitis[J].World Journal of Gastroenterology,2006,12(41):6711-6714. 被引量:13
-
8Olivier Detry,Arnaud De Roover,Pierre Honoré,Michel Meurisse.Brain edema and intracranial hypertension in fulminant hepatic failure:Pathophysiology and management[J].World Journal of Gastroenterology,2006,12(46):7405-7412. 被引量:12
-
9Daniel G. Cyr,Mary Gregory,Evemie Dube,Julie Dufresne,Peter T. K. Chan,Louis Hermo.Orchestration of occludins, claudins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans[J].Asian Journal of Andrology,2007,9(4):463-475. 被引量:3
-
10周其全,王静,汪云利,李爱冬,程丽.炎症介质在高原暴露下血脑屏障通透性改变中的作用及相互关系[J].中国应用生理学杂志,2007,23(3):281-285. 被引量:9
二级引证文献4
-
1吴娟.幽门螺杆菌在轻微肝性脑病发病机制中的作用及HP根治治疗后临床影响[J].中华医院感染学杂志,2013,23(15):3642-3644. 被引量:11
-
2沈燕.雷贝拉唑肠溶胶囊致肝硬化患者神经系统不良反应1例[J].右江民族医学院学报,2014,36(6):922-922. 被引量:3
-
3程飞.MRI配合多层螺旋CT对肝性脑病的诊断价值[J].临床医学,2016,36(9):86-87. 被引量:2
-
4张叶凡,于万有,陈冬玲,李谦.人工肝治疗急(亚急)性肝衰竭合并肝性脑病的中短期预后评估[J].实用器官移植电子杂志,2020,8(4):252-255. 被引量:8
-
1曹海霞,范建高.特殊人群肝豆状核变性诊治进展[J].实用肝脏病杂志,2015,18(1):89-92. 被引量:7
-
2P. E. Sijens,H. Alkefaji,R. J. Lunsing,F. J. van Spronsen,L. C. Meiners,M. Oudkerk,田凤娟,王丹.急性肝衰竭患儿颅脑多体素1H-MRS定量分析[J].国际医学放射学杂志,2009,32(1):91-91.
-
3李丙中.静脉毛花甙C、胺碘酮治疗快速阵发性心房颤动的临床体会[J].中国医药指南,2013,11(8):137-138. 被引量:1
-
4杨建辉,黄延寿.星状神经节阻滞治疗偏头痛50例报告[J].卒中与神经疾病,1996,3(1):31-32.
-
5李春元.肝性脑病的治疗近况[J].国外医学(流行病学.传染病学分册),1998,25(1):38-41. 被引量:2
-
6韩涛,李莹.急性肝衰竭并发脑水肿研究现状[J].传染病信息,2010,23(2):72-75. 被引量:3
-
7徐成润,杨铮,饶日春,郑瑞丹.肝豆状核变性并发急性溶血及急性肝衰竭1例报告[J].第一军医大学学报,2003,23(11):1160-1160.
-
8王姗姗,陈寿权,李章平,王卫,王万铁.大鼠心肺复苏后脑水肿的变化及肾上腺素对脑水肿的影响[J].实用医学杂志,2006,22(10):1114-1116.
-
9尹变利.可逆性后部脑病综合征临床、影像特点及预后分析[J].中国临床研究,2013,26(2):131-132.
-
10高金明.双肺部实变、低氧血症[J].中国呼吸与危重监护杂志,2005,4(3):242-242.