摘要
目的 预测SARS冠状病毒E蛋白的HLA A 0 2 0 1限制性细胞毒性T淋巴细胞 (CTL)表位。方法 联合应用超基序法和量化矩阵法。结果 预测出 13个九肽CTL表位。结论 通过对SARS冠状病毒E蛋白抗原CTL表位进行预测 ,从而为SARS冠状病毒E蛋白CTL表位的实验探测和鉴定提供了线索 。
Objective To predict the HLA A *0201 restricted CTL epitopes (nonamers) in SARS coronavirus (SARS CoV) E protein. Methods The CTL epitopes of E protein were predicted by using supermotif method combined with quantitative matrix method. Results Thirteen HLA A *0201 restricted CTL epitope candidates were predicted in SARS CoV E protein. Conclusion The prediction of the CTL epitopes in SARS CoV E protein will benefit the identification of CTL epitopes by experiment. Those results are of importance for immune recognition and vaccine design for SARS CoV.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第12期1065-1067,共3页
Journal of Third Military Medical University
基金
国家重点基础研究发展规划资助项目 ( 2 0 0 3CB514 10 8)~~
