摘要
为观察CD117分子在急性早幼粒细胞白血病 (APL)中的表达及探讨其意义 ,采用三色流式细胞术对 2 2例APL骨髓白血病细胞表面CD117的表达进行分析。结果 :CD117在APL中的表达率为 1 9/2 2 ,在急性粒细胞白血病(AML M1)和AML M2 中的表达率分别为 2 /2和 1 8/2 1。 1 9例CD117+ 的APL患者中 ,1 8例CD34 - 、HLA DR- ,1例部分细胞HLA DR+ 。提示 :APL患者有较高水平的CD117表达 ,CD117与CD34 、HLA DR联合进行多色流式细胞术分析 ,可用于APL微小残留病灶的检测。
The aim was to investigate the expression of CD 117 in acute promyelocytic leukemia and its significance. The expression of CD 117 was detected using three-color flow cytometry. CD 117 was positive in 19/22 of patients with acute promyelocytic leukemia(APL), in 2/2 and 18/21 of patients with AML-M 1 and AML-M 2 respectively. Among nineteen APL patients with CD 117 , eighteen were CD 34 - and HLA-DR -. Only one patient was partial HLA-DR +. There was high level expression of CD 117 in acute promyelocytic leukemia. Minimal residual disease of APL can be detected using multi-color flow cytometry to analyze the expression of CD 117 , CD 34 and HLA-DR.
出处
《首都医科大学学报》
CAS
2004年第2期227-229,共3页
Journal of Capital Medical University
