摘要
目的 研究p73在子宫内膜癌中的蛋白表达情况 ,以探讨其在子宫内膜癌发生发展中的可能作用。方法 采用免疫组化SP法测定 5 8例子宫内膜癌标本 ,2 0例子宫内膜中、重度不典型增生标本和 2 4例正常子宫内膜标本中p73的蛋白表达情况。结果 ①p73在子宫内膜癌中表达阳性率为 5 3.4 5 % ,在子宫内膜中、重度不典型增生中阳性率为 2 5 .0 0 % ,在正常子宫内膜中阳性率为 4 .17% ,各组相比 ,差异有显著意义 (P <0 .0 5 )。②p73在子宫内膜癌各期的阳性率分别为 :Ⅰ期 31.82 % ,Ⅱ期 5 6 .2 5 % ,Ⅲ～Ⅳ期 75 .0 0 % ,Ⅲ～Ⅳ期与Ⅰ～Ⅱ期相比 ,差异有显著意义 (P <0 .0 5 ) ;且p73的阳性率随组织学分级、肌层浸润深度、淋巴转移而升高 (P <0 .0 5 )。③p73“ +”的患者比p73“ -”的患者预后差 (P <0 .0 5 )。结论 p73蛋白表达异常在子宫内膜癌的发生发展中可能发挥重要作用 ;p73蛋白过表达与子宫内膜癌患者的预后有关 ,可能作为子宫内膜癌患者判断预后的指标之一。
Objective To investigate the expressions of p73 in endometrial carcinoma and their clinical significance and analyze the relationship of their expressions with the development of endometrial carcinoma.Methods Expression of p73 proteins was retrospectively studied by immunohistochemisty in paraffin sections from 24 normal endometrium(proliferative phase:12,secretive phase:12),20 atypical hyperplasia and 58 endometrial carcinoma.Results ①The positive expression rate of p73 in endometrial carcinoma,atypical hyperplasia and normal endometrium were 53.45%,25.00% and 4.17%,respectively.There were great differences in positive rates(P<0.05).②The positive rates of p73 in different clinical stage of endometrial carcinoma was Ⅰ:31.82%,Ⅱ:56.25%,Ⅲ Ⅳ:75.00%.There were also great differences in positive rates between group Ⅲ Ⅳ and group Ⅰ Ⅱ.In accordance with histological grade,myometrial invasive depress,lymph transference,the positive rate of p73 increased.③Patients with p73(+) had worse results than p73(-) ones(P<0.05).Conclusion The abnormal expression of p73 probably play a major role in the development of endometrial carcinoma.The over expression of p73 relates to the prognosis of endometrial carcinoma patients.Protein p73 may be a predictable factor.
出处
《哈尔滨医科大学学报》
CAS
2004年第3期263-265,共3页
Journal of Harbin Medical University
关键词
P73
子宫内膜癌
免疫组化
抑癌基因
p73
endometrial carcinoma
immunlhistochemistry
tumor suppressor gene
