摘要
以标题化合物(tbpOH)为配体合成了4种拟SOD模型配合物,对配体及配合物进行了红外、紫外和元素分析表征,并在HF/6-31G基组水平上对配体进行了量子化学计算,由分析计算结果可知,tbpOH可以成为较为理想的组氨酸模拟物.采用经典的邻苯三酚自氧化法对合成的拟SOD模型配合物进行了活性测定,可知所合成的模型配合物均具有一定的拟SOD活性,且活性顺序为Cu2(tbpO)·(CH3COO)·(ClO4)3·2C2H6O·H2O>Cu2(tbpO)·(C6H5COO)·(ClO4)3·1.5C2H6O>Fe2(tbpO)·(CH3COO)·(ClO4)5·CH3OH·H2O>Mn2(tbpO)·(C6H5COO)2·(ClO4)2·4H2O.
Four kinds of SOD mimics were synthesized with N,N,N',N'-tetrakis (benzimidazol-2-ylmethyl)-2-hydroxy-1,3-diaminopropane as ligand. And a quantum chemistry calculation of tbpOH was performed on HF/6-31G base set. All the complexes and ligand were characterized with elemental analysis, UV and IR spectroscopy. The ability of these SOD mimics to scavenge O_2^(-·) was tested by means of pyrogallol autoxidation. The results showed that their activity sequence was Cu_2(tbpO)·(CH_3COO)·(ClO_4)_3·2C_2H_6O·H_2O>Cu_2(tbpO)·(C_6H_5COO)·(ClO_4)_3·1.5C_2H_6O>Fe_2(tbpO)·(CH_3COO)·(ClO_4)_5·CH_3OH·H_2O>Mn_2(tbpO)·(C_6H_5COO)_2·(ClO_4)_2·4H_2O.
出处
《天津师范大学学报（自然科学版）》
CAS
2004年第2期5-8,共4页
Journal of Tianjin Normal University：Natural Science Edition
基金
天津市教委重点学科资助项目(97202)
