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基因工程在骨髓间充质干细胞治疗心肌梗死中的应用 被引量：4

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摘要 随着溶栓和急诊冠脉介入的广泛开展,急性心肌梗死(AMI)的死亡率明显降低。但是心肌梗死后心室重构以及缺血性心肌病的发生严重影响了患者的预后。要使心肌细胞再生乃至衰竭的心脏恢复功能仍是一项巨大的挑战。研究提示骨髓间充质干细胞(BMSCs)可参与受损心肌的重建,可以提高左室射血分数,降低左心室收缩末期和舒张末期容积、减少梗死面积并改善左室重构〔1〕。
作者 王曼 李树仁
机构地区 河北医科大学附属河北省人民医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2015年第1期269-271,共3页 Chinese Journal of Gerontology
关键词 基因工程 充质干细胞 心肌梗死
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献25

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共引文献12

同被引文献49

  • 1周青,郭瑞强,陈新军,陈金玲.经胸超声心动图对3种兔心力衰竭模型的检测[J].中国超声医学杂志,2005,21(5):325-327. 被引量：7
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  • 10Matsuura K, Nagai T, Nishigaki N, et al. Adult cardiac Sca-l-positive cells differentiate into beating cardiomyocytes. J Biol Chem. 2004;279(12):11384-11391.

引证文献4

二级引证文献11

中国老年学杂志
2015年 第1期

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