摘要
目的:总结CD146对黑色素瘤多方面生物特征的影响,揭示靶向抑制CD146可能在未来人类黑色素瘤的预防和治疗中发挥作用。方法:应用Medline、PubMed及CNKI期刊全文数据库检索系统,以"CD146和黑色素瘤"为关键词,检索自建库至2012-04的相关文献。纳入标准:1)CD146与黑色素瘤的相关性;2)CD146的结构;3)黑色素瘤的治疗及预后。符合分析的文献31篇。结果:CD146作为最近发现的免疫球蛋白家族成员,对调节黑色素瘤的多种生物学特征有重要作用。CD146虽然不影响体外瘤细胞增殖,但能增强体外瘤细胞的侵袭性、运动性、转移性、黏附性和在裸鼠体内的致瘤性及增加瘤内血管的密度,从而促进黑色素瘤的发生和发展。结论:通过阐述CD146对黑色素瘤多方面的作用,有助于揭示黑色素瘤的发病机制和为研发有效治疗方案提供依据。
OBJECTIVE:To summarize articles related to the effect of CD146 on various biological characteristics of melanoma and reveal the possibility of targeting CD146 in the design of future strategies for the prevention and treatment of human melanoma.METHODS: The related works were searched by 'CD146,melanoma' as Keywords in Medline,PubMed and CNKI database until April 2012.Totally 31 papers were selected and analyzed according to the inclusion criteria as follows:1) the correlation between CD146 and melanoma;2) the construction of CD146;3) the treatment and prognosis of melanoma.RESULTS: CD146 as a recently identified member of immunoglobulin gene superfamily,plays an important role in various biological characteristics of melanoma.Though CD146 does not affect the proliferation of melanoma cells in vitro,it can reinforce the invasion,motion,metastasis,adhesion and tumorigenicity in nude mice,and augment the angiogenesis in vivo or vessel-like tube formation in vitro.CONCLUSTION: The research of the role of CD146 in various biological characteristics of melanoma could reveal nature of melanoma and provide a foundation to develop effective treatments.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第2期157-160,共4页
Chinese Journal of Cancer Prevention and Treatment
