摘要
芳香烃受体(Aryl hydrocarbon receptor,AhR)是一个配体依赖性激活的转录因子,配体与AhR结合后,从而引起一系列下游基因的表达和代谢酶的活化,与肿瘤发生发展的关系密切。根据AhR配体结构和功能的不同对其在肿瘤形成中的作用进行综述,以便为肿瘤的治疗提供新的靶点。
Aryl hydrocarbon receptor (AhR) is a ligand-dependent activation of transcription factor, which is activated by a large variety of ligands, resulting in the expression of metabolic enzymes and a series of downstream gene activation, and closely related with tumor development . Now a review for AhR ligands with different structural and functional and its relationship with tumor, in order to provide a new target for tumor therapy.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第1期150-152,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
国家自然科学基金(81260499
81160406)
关键词
芳香烃受体
配体
激动剂
拮抗剂
肿瘤
aryl hydrocarbon receptor
ligand
agonists
antagonists
tumor
