摘要
通过查阅近几年国内外HPMC胶囊的相关文献,分析了HPMC胶囊的应用情况及优势,重点介绍了HPMC胶囊的体内外研究现状,深入探讨了HPMC胶囊与传统明胶胶囊在体外崩解释放和体内生物利用度及药动学方面的差异,并对HPMC胶囊的应用前景进行了展望。
After a literature review of the HPMC capsules, the research status of the HPMC capsules in vivo and in vitro are summarized, including the application status, the superiority over hard gelatin capsules and in particularly the disintegration release in vitro and bioavailability in vivo, as well as pharmacokinetics difference compared with conventional gelatine capsules, are explored in depth. Finally, the future applications of HPMC capsules are prospected.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第1期138-141,共4页
Chinese Journal of Biochemical Pharmaceutics
基金
江苏省博士后科研资助计划(1301012A)
江苏政府留学奖学金(2013)
国家自然科学基金资助项目(81170492)
关键词
HPMC胶囊
体内外研究
崩解
生物利用度
药动学
HPMC capsule
in vivo and in vitro research
disintegration
bioavailability
pharmacokinetics
