摘要
目的探讨静脉输注免疫球蛋白G(IVIG)对慢性不可预料应激抑郁模型大鼠的影响。方法慢性不可预料应激造模大鼠,分为IVlG+应激组(MG组,N=6)和单纯应激组(CUS组,n=6),采用糖水偏好实验、强迫游泳实验和BrdU标记检测海马齿状回神经元再生,分析IVIG对抑郁模型大鼠的作用。结果 IVIG组大鼠糖水偏好消耗显著大于CUS组(P<0.01),强迫游泳实验lVIG组不动时间显著小于CUS组(P<0.01);IVIG组海马区域BrdU阳性细胞数对比CUS组阳性细胞个数具有显著差异(P<0.01)。结论 IVIG具有抗慢性不可预料应激造成的抑郁症状,其作用可能是通过消减循环炎性细胞因子发挥作用。
Objective To investigate the effect of intravenous immunoglobulins G on rat subjected to chronic un-predictable stress. Method Rats were randomly divided into 2 groups (IVIG+stress group and stress-only group). Sucrose preference test, force swim test and neurogenesis analyze were used to analyze the effect of IVIG on rats in stress group. Results Sucrose consumption in IVIG group was significantly more than CUS group(P<0.01), while non floating time of force swim was significantly lower than CUS group(P<0.01). The difference of BrdU positive cell number in Hippocampus between two groups was significant(P<0.01). Conclusion IVIG show an antidepressant like effect, the mechanism may be involved in eliminate inflammatory cytokine of peripheral circulation.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第1期32-34,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
国家自然科学基金资助项目(81102280)
关键词
免疫球蛋白G
抑郁
海马
immunoglobulin G
depression
hippocampus
