摘要
目的 研究氢溴酸加兰他敏分散片的处方组成及制备工艺。方法 制备氢溴酸加兰他敏分散片 ,制定质量控制标准 ,采用高效液相色谱法测定其含量、溶出度 ,并考察其稳定性。结果 氢溴酸加兰他敏分散片稳定性较好 ,质量控制方法可行 ,高效液相色谱法测定该片含量的平均回收率为 10 0 2 % (RSD为 1 4 5 % )。结论 本品处方合理 ,工艺成熟 ,质量稳定 ;为临床治疗老年性痴呆症提供了一种易于服用且奏效较快的新制剂。
Objective To investigate the composition and preparation method of galanthamine hydrobromide dispersion tablets. Method The glanthamine hydrobromide dispersion tablets was prepared and the method for the quality control was studied. A HPLC method was established for determining the content and dissolution and stability of the samples. Result The average recovery of HPLC method to determine galanthamine hydrobromide dispersion tablets was 100.2% with RSD=1.45%. Conclusion The galathamine hydrobromide dispersion bablets will play an important part for treatment of Alzheimer's Disease as a result of its reasonable formulation good qunlity and stability.
出处
《江苏药学与临床研究》
2004年第3期14-17,共4页
Jiangsu Pharmacertical and Clinical Research
基金
江苏省药学会临床协作组"奥富康科研基金"课题
关键词
氢溴酸加兰他敏分散片
含量测定
溶出度
稳定性
Galanthamine hydrobromide dispersion tablets
Content detemination
Dissolution testing
Stability.
