摘要
采用光化学扩增法测定小鼠血液和脑组织中超氧化物歧化酶(SOD)含量,用硫代巴比妥酸分光光度法测定小鼠血浆及脑组织中脂质过氧化物—丙二醛(MDA)含量,进而分析人参固本(丸)口服液的抗氧化作用。结果表明:人参固本丸及其口服液均可提高因甲状腺素片、利血平片所致的肾阴虚模型小鼠血液和脑组织中 SOD 活力,降低血浆及脑组织中 MDA 的含量,具有较强的抗氧化能力和抑制体内脂质过氧化反应的作用。
17 swiss male mice were divided into four groups:group Ⅰ (control) were administered through gastric tube with 0.9% NS 0.5ml/ perday;group Ⅱ,with thyrine 3mg/per day and reserpin 0.02mg/perday; group Ⅲ,with thyrine 3mg/perday,reserpin 0.02mg/perday,renshenguben liquid 0.25/perday;group Ⅳ,with thyrine 3mg/perday,reserpin 0.02mg/ perday,renshenguben liquid 0.5ml/perday.The whole course lasted 10 days. The results showed that the content of SOD in the blood and the brain in group Ⅲ and Ⅳ increased significantly as compared with that in group Ⅱ, that the content of liqid peroxide in the blood and brain in group Ⅲ,Ⅳ was significantly less than that in group Ⅱ.The results suggest:1. renshenguben lipuid can raise the activity of SOD;2.It has the function of antioxidation in blood and brain in model mice of shen yin deficiency from thyrine and reserpin.
出处
《山东中医药大学学报》
1991年第6期67-68,70-71,共4页
Journal of Shandong University of Traditional Chinese Medicine
关键词
人参固本丸
抗氧化
实验研究
小鼠
Renshenguben pill
Anti-oxidation
Kidney deficiency of yin
Mice
