摘要
测定10例用庆大霉素(GM)治疗的婴儿肺炎(G 组)的 N-乙酰-β氨基葡萄糖酶(NAG)、β-D-半乳糖苷(GAL)以及庆大霉素血药浓度,以未用 GM 组的婴儿作对照(Ⅰ组)。发现尿 NAG 与 GAL 的变化有相关关系(γ=0.8),GAL/NAG 比值(G/N)明显降低(P<0.05),同时与 GM 谷浓度有相关关系(γ=-6.5)。结果表明:GM 谷浓度在肾毒性作用中意义较大,而 G/N 是反映 GM 肾毒性作用及修复的较为敏感的指标。
Gentamicin nephrotoxicity was investigated on 2 group of infants:pneumonia with (group G) and without gentamicin (group I).Enzyme activity of β-galactosidase (GAL) and N-acetyl- β-glucosaminidase (NAG),ratio of GAL/NAG (G/N) in urine and concertration of gentamicin in blood were tested.G/N was higher in group G than that in group I (P<0.05) and interrelated with lower concentration of gentamicin (R=-0.65).GAL was low at first but high at last and interrelated with NAG in urine too (R=0.8).It suggests that GAL is the indx of the sensitivity or responsibility of the tubular cells against the neghrotoxic agents.And changes of G/N is a sensitive index for earlier gentamicin nephrotoxicity and recovery.
出处
《中日友好医院学报》
1992年第3期163-165,共3页
Journal of China-Japan Friendship Hospital
