摘要
目的:分析痛风患者大动脉粥样硬化特征,寻找其规律性。方法:选择近期做完腹部CT检查的55例痛风患者按相同性别、年龄、身高、体质量和其他心血管危险因素与血尿酸正常1∶1配对(对照组),比较腹主动脉钙化率和钙化体积。结果:55例痛风患者中,腹主动脉钙化率为74.5%(41例),钙化体积为犤(0.76±0.19)cm3犦,明显高于对照组(χ2=12.274,P<0.001和t=3.953,P<0.01)。在按不同血尿酸水平分组后,重度升高组(≥150mg/L,11例)的腹主动脉钙化体积犤(0.99±0.31)cm3犦明显高于中度(90～140mg/L,21例)犤(0.85±0.26)cm3犦和轻度升高组(<90mg/L,23例)犤(0.67±0.22)cm3犦(t=2.145和3.164,P<0.01和0.05)。在按有无合并危险因素及合并多少分组后,合并多项危险因素患者(24例)的腹主动脉钙化体积和钙化率明显高于不合并组(t=3.375,P<0.01和χ2=7.309,P<0.01)。结论:痛风患者常有较严重的大动脉粥样硬化,大动脉粥样硬化发生频度和程度与痛风患者血尿酸升高水平和合并危险因素多少有一定关系。
AIM:To analyze the characteristics of aortic atherosclerosis in patients with gout, and to explore its regularity. METHODS:After examining abdominal CT,55 patients with gout were matched with normal subjects with normal uric acid(control group) at the ratio of 1 to 1 by same sex,age,height,body mass and other cardiovascular risk factors,to compare the calcification rate and volume of abdominal aorta. RESULTS:The calcification rate and volume of abdominal aorta were 74.5%(41 cases)and(0.76±0.19)cm3 for the patients with gout,obviously higher than those in the control group(χ2=12.274,P< 0.001 and t=3.953,P< 0.01). According to uric acid level,the calcification volume in severe elevated group(≥15.0 mg/L,11 cases)[(0.99±0.31) cm3] was obviously higher than those in the moderate(90-140 mg/L,21 cases)[(0.85±0.26) cm3] and mild elevated groups(< 90 mg/L,23 cases)[(0.67±0.22) cm3](t=2.145,3.164,P< 0.01 and 0.05).According to whether the subjects have risk factors or not, the calcification rate and volume of abdominal aorta in the multiple risk factors group(24 cases) were obviously higher than those in the non risk factor group(13 cases)(t=3.375,P< 0.01 and χ2=7.309,P< 0.01). COUCLUSION:Patients with gout are always complicated with severe aortic atherosclerosis,and the incidence rate and degree have a certain relation with the elevated level of uric acid and risk factor of the patients.
出处
《中国临床康复》
CSCD
2004年第18期3502-3503,共2页
Chinese Journal of Clinical Rehabilitation
