摘要
对LaForge合成酰基吡啶的方法进行了改进,并用改进的方法合成了6个酰基吡啶类化合物:3-乙酰吡啶;3-(3-甲基丁酰)吡啶;4-仲丁基-3-(2-甲基丁酰)吡啶;4-异丙基-3-(2-甲基丙酰)吡啶;4-乙基-3-丙酰吡啶;4-N丙基-3-丁酰吡啶。其中,3个4-烷基-3-酰基吡啶(除4-正丙基-3-丁酰基吡啶外)尚未见报道。此外,将Barbier合成醇的一步反应方法改进后移用于上述酰基吡啶的合成,结果也获得成功。将上述6个化合物作为烟草添加剂加到混合型卷烟和烤烟型卷烟中,经有关专家评吸,认为该6种化合物能增加烟草香味,降低刺激性,改进吃味,可应用于卷烟香料的调制。
LaForge method for Synthesis of acyl—pyridines has been modified, and six acyl—pyridines have been Synthesized: namely 3-actylpyridine; 3—(3—methylbutanoyl) pyridine, 4—sec—butyl—3— (2—methylbutanoyl) pyridie, 4—iso—propyl—3—(2—methylpropionyl)—pyridine, 4—ethyl 3—propionylpyridine, 4—n—propyl—3—butanoyl—pyridine.Except 4—n—propyl—3— butanonylpyridine, three 4—alkyl—3—acylpyridine have not been reported in literature.The yield of 3-acetylpyridine and 4—n—propyl—3—butan—Oylpyridine have been improved in the synthesis.Besides, the method of Barbier One—step procedure for the preparation of alcohols had been modified and was also successfully used for the synthesis of above mentioned acyl—pyridines.The six compounds were added into Virginia type and blended type cigarettes as tobacco additives.It was found by sensory test expert that the six compounds synthesized can enhance the cigarette flavor, reduce irritation and improve the taste of cigarette smoke.They could be used as ingredient in cigarette flavoring compounds.
出处
《中国烟草学报》
EI
CAS
CSCD
1992年第2期10-15,共6页
Acta Tabacaria Sinica
