THE STUDY ON IN VITRO METABOLISM OF BUTYLPHTHALIDE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY

THE STUDY ON IN VITRO METABOLISM OF BUTYLPHTHALIDE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY

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摘要 The in vitro metabolism o. butylphthalide (HBP) by rat liver microsomes was studied in this paper. Capillary GC/MS and BSTFA/1%TMCS derivatization were used for the separation and structure identification of the six metabolites. 3-Hydroxylation and r-hydroxylation have been proved to be the main metabolism pathways of HBP by rat liver microsomes. The in vitro metabolism o. butylphthalide (HBP) by rat liver microsomes was studied in this paper. Capillary GC/MS and BSTFA/1%TMCS derivatization were used for the separation and structure identification of the six metabolites. 3-Hydroxylation and r-hydroxylation have been proved to be the main metabolism pathways of HBP by rat liver microsomes.

作者 Shi Hua PENG Tong Hui ZHOU

机构地区 Institute of Materia Medica

出处《Chinese Chemical Letters》 SCIE CAS CSCD 1995年第1期55-58,共4页 中国化学快报(英文版)

关键词 GAS CHROMATOGRAPHY BY BUTYLPHTHALIDE

分类号 O62 [理学—有机化学]

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Chinese Chemical Letters

1995年第1期

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THE STUDY ON IN VITRO METABOLISM OF BUTYLPHTHALIDE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY

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