~99m Tc标记单克隆抗体在肿瘤放免显像中的应用进展
摘要
放射免疫显像已成为对肿瘤进行诊断的重要手段之一。目前认为,在用于放免显像核素中99mTc是比较理想的放射性核素。本文就放射性核素99mTc标记单克隆抗体和单克隆抗体片段在肿瘤放免显像中的基础、临床研究和存在的问题及研究方向等进行综述,以探讨早期肿瘤导向诊断方法。
参考文献13
-
1Baum RP,Hertel A,Loren ZM,et al.99m Tc-labeled anti-CEA monoclonalantibody fragment for tummour immunoscintigraphy: first clinical result. Nuclear Medicine Communications . 1989
-
2Lind P.Lechner P.Eber O,et al.A prospective study of CEA immunoscintigraphy with a Tc-99m-labeled antibody fragment (immu-4Fab’)in colorectal cancer patients. The Journal of Nuclear Medicine . 1991
-
3Maguire RT.Schmelter RF,Shanken T,et al.Imaging with indium-111-labeled anticarci-noembryonic antigen monoclonal antibody ZCE-025 of recurrent colorectal or carcinoembryonic antigen-producing cancer in patienes with rising serum carnoembryonic antigen levels and occult metastases. Journal of Clinical Oncology . 1990
-
4Beatty JD.Hyams DM,Morton BA.et al.Impact of radiolabeled antibody imaging on manag- ment of colon cancer. The American Journal of Surgery . 1989
-
5Larson SM.Clinical radioimmunodetection-(1978-1988) overview and suggestions for standardzation of clinical trials. Cancer Research . 1990
-
6Goldenberg DM,Goldenberg H,Sharkey RM,et al.Clinical studies of cancer radioimmun-odetection with 123I or 99mTc. Cancer Research . 1990
-
7Perkins AC,Pimm MC.Immunoscintigraphy: practical aspects and clinical application. . 1991
-
8Yokoyama K,Carrasquillo J A. Change AE.et al.Differences in bidistribution of indium-111 and io- dine-131-labeled B 72. 3 monoclonal-antibodies in patients with colorectal cancer. The Journal of Nuclear Medicine . 1989
-
9Colcher D,Bird R,Roselli M,et al.In vivo tumortargeting of a recombinant single chain antigen binding protein. Journal of the National Cancer Institute . 1990
-
10David JK,Turner A.Andrew PH.et al.Improved tumor targeting with chemically cross-linked recombinant antibody fragment. Cancer Research . 1994
-
1钭理强,俞莉章,郭应禄.单克隆抗体在前列腺癌显像和治疗中的应用[J].中华泌尿外科杂志,1997,18(9):571-572.
-
2张晓鹏,陈峻青,何三光.肿瘤导向诊断的基本概念及现状[J].中国实用外科杂志,1996,16(10):583-584. 被引量:1
-
3陈志南,刘彦仿.肝癌单克隆抗体HAb18在人体肝癌导向诊断中的意义和应用[J].中华肿瘤杂志,1992,14(1):9-12. 被引量:8
-
4杨子义,么崇正.抗肺癌单克隆抗体片段的制备及其在放射免疫显像中的应用[J].中华核医学杂志,1991,11(3):145-147. 被引量:8
-
5张银汉.具有肿瘤导向的T细胞[J].国外医学情报,2002,23(12):25-25.
-
6Schl.,J.,钱玉宁.单克隆抗体肿瘤导向的革新:探索诊断与治疗[J].美国医学会杂志(中文版),1989,8(4):219-221.
-
7赵风.原发性肝癌的导向诊断和治疗[J].中国中医药咨讯,2010(11):66-66.
-
8张春丽,俞莉章,王荣福,丁义,朱绍莉,李宁忱.膀胱癌、输尿管癌导向诊断与导向治疗的临床基础研究[J].医学研究通讯,2002,31(7):22-23. 被引量:6
-
9邢春根,刘根寿,田斌,何广仁,鲍君杰,陈易人.放免导向诊断大肠癌[J].实用肿瘤杂志,2000,15(1):14-16.
-
10邢春根,刘根寿,田斌,李军成,吴浩荣,何广仁,鲍君杰,吴锦昌.^(131)I—C_(50)放免导向诊断大肠癌的研究[J].苏州医学院学报,1996,16(3):427-428.