摘要
为研究维拉帕米在高血压患者的药代动力学及药效学,采用荧光分光光度法测定24例高血压患者单剂量口服维拉帕米片160mg后的血药浓度,同时观察血压及心率。结果表明,口服维拉帕米的药时曲线符合一级吸收一室模型,血药浓度达峰时间为2.33±1.16h,峰浓度为275±111μg·L^(-1),t_(1/2)为5.22±2.08h,降血压的最大效应时间比血药浓度达峰时间明显滞后。提示,维拉帕米血药浓度与降血压效应呈不完全平行关系。
To study the pharmacokinetics and pharmacodynamics of verapamil in patients with hy-pertension , the verapamil concentration in plasma was determined by fluorospectrophotometry after oral ad-ministration of 160 mg verapamil tablet to each of 24 patients with hypertension, at the same time, the blood pressure and heart rate were observed. The results showed that the plasma concentration - time curves were conformed to be one compartment model with a first order absorption, the tmax was 2.33h±?1. 16h, the Cmax was 275μg ·L-1±111μg·L-1, the t1/2 was 5.22h±?2.08h. The time of maximum hypoten-sive effect was later than the peak concentration time. It was suggested that the concentration of verapamil orally administered in plasma doesn' t fully parallel with the hypotensive effect.
出处
《解放军药学学报》
CAS
1998年第3期131-133,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
维拉帕米
药代动力学
药效学
verapamil
Pharmacokinetics
pharmacodynamics
