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先天性心脏病相关转录因子Csx/Nkx2.5基因的研究 被引量：2

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摘要 先天性心脏病(CHD)是常见的危害儿童健康的先天性疾病。调控心脏发育基因突变是CHD常见原因,同源盒基因Csx/Nkx2.5是心脏发育过程中最早表达的转录因子,该基因突变影响心脏发育,导致CHD。检测Csx/Nkx2.5基因突变可作为产前CHD诊断的一项指标。
作者 陈萍 常才
机构地区 复旦大学附属妇产科医院
出处 《国外医学（妇产科学分册）》 2004年第3期164-167,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
关键词 先天性心脏病 转录因子 CHD Csx NKX2.5基因 分子机制
分类号 R541.1 [医药卫生—心血管疾病]
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参考文献20

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同被引文献12

  • 1Reamon-Buettner S M, Hecker H, Spanel-Borowski K, et al. Novel Nkx2-5 mutations in diseased heart tissues of patients with cardiac malformations[J]. Am J Pathol, 2004, 164(6): 2117-2125.
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  • 7Marcel A G, van der Heyden L, Marian J A, et al. P19 em- bryonal carcinoma cells: a suitable model system for cardiac electrophysiological differentiation at the molecular and functional level[J]. Cardiovasc Res, 2003,58(2) : 410-422.
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  • 9Monzen K, Zhu W D, Kasai H, et al. Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes [J]. Biochem Biophys Res Commun, 2002,298(4):493-500.
  • 10Small E M, Krieg P A. Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF[J]. Dev Biol, 2003,261(1): 116-131.

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国外医学（妇产科学分册）
2004年 第3期

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