Enantioselective O-allylic alkylation of Morita-Baylis-Hillman carbonates with oxime 被引量：1

Enantioselective O-allylic alkylation of Morita-Baylis-Hillman carbonates with oxime

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摘要 The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee. The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee.

作者 HU ZeKai CUI HaiLei JIANG Kun CHEN YingChun

机构地区 Key Laboratory of Drug-Targeting and Drug Delivery System of Education Ministry

出处《Science China Chemistry》 SCIE EI CAS 2009年第9期1309-1313,共5页 中国科学（化学英文版）

基金 Supported by the National Natural Science Foundation of China (Grant No. 20772084)

关键词 asymmetric organocatalysis ALLYLIC alkylation OXIME Morita-Baylis-Hillman CARBONATES asymmetric organocatalysis allylic alkylation oxime Morita-Baylis-Hillman carbonates

分类号 O643.32 [理学—物理化学]

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Enantioselective O-allylic alkylation of Morita-Baylis-Hillman carbonates with oxime 被引量：1

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