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Development and application of genotyping technologies 被引量：6

Development and application of genotyping technologies
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摘要 With the completion of Human Genome Project,International HapMap Project and the publication of copy number variation in human genome,a great number of accurate,rapid,and cost-effective technologies for SNP analysis have been developed,promoting the research of the complex diseases.This article presents a review of widely used genotyping techniques,and the progress and prospect in the study of complex diseases in terms of the projects and achievements of Chinese National Human Genome Center at Shanghai(CHGCs). With the completion of Human Genome Project,International HapMap Project and the publication of copy number variation in human genome,a great number of accurate,rapid,and cost-effective technologies for SNP analysis have been developed,promoting the research of the complex diseases.This article presents a review of widely used genotyping techniques,and the progress and prospect in the study of complex diseases in terms of the projects and achievements of Chinese National Human Genome Center at Shanghai(CHGCs).
作者 SHI JinXiu,WANG Ying & HUANG Wei Shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center at Shanghai,Shanghai 201203,China
出处 《Science China(Life Sciences)》 SCIE CAS 2009年第1期17-23,共7页 中国科学（生命科学英文版）
基金 Supported by the National Natural Science Fundation for Distinguished Young Scholars (Grant No.30625019) Shanghai Rising-Star Program (Grant No.08QA14053)
关键词 single NUCLEOTIDE POLYMORPHISM COPY NUMBER VARIATION complex disease single nucleotide polymorphism,copy number variation,complex disease
分类号 Q75 [生物学—分子生物学]
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参考文献10

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  • 2Yan W L,,Gu D F.Issues on association studies on complex diseases[].J Genet Genomics.2004
  • 3Zhang XJ,He PP,Wang ZX,et al.Evidence for a major psoriasis susceptibility locus at 6p21 (PSORS1) and a novel candidate region at 4q31 by genome-wide scan in Chinese Hans[].Journal of Investigative Dermatology.2002
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同被引文献129

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Science China(Life Sciences)
2009年 第1期

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