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Isolation,structural determination and cytotoxic activity of two new ceramides from the root of Isatis indigotica 被引量:7

Isolation,structural determination and cytotoxic activity of two new ceramides from the root of Isatis indigotica
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摘要 Two new ceramides were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as 1-O-β-D-glucopyranosyl-(2S, 3R)-N-(2'-hydroxypentacosanoyl)-octadeca-11E-sphingenine (1) and 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2'-hydroxyhe xacosanoyl)-octadeca-11E-sphingenine (2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method. Two new ceramides were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as 1-O-β-D-glucopyranosyl-(2S, 3R)-N-(2′-hydroxype-ntacosanoyl)-octadeca-11E-sphingenine (1) and 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2′-hydroxyhe xacosanoyl)-octadeca-11E-sphingenine (2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method.
出处 《Science China Chemistry》 SCIE EI CAS 2009年第5期621-625,共5页 中国科学(化学英文版)
关键词 Isatis indigotica CERAMIDES CYTOTOXIC ACTIVITY Isatis indigotica ceramides cytotoxic activity
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