摘要
目的探讨各种不同病因所致抽搐患儿血清中生物标志物浓度变化及年龄相关性。方法检测各种不同病因所致抽搐患儿入院后24h内血清中S100β、NSE浓度,比较不同病因组及不同年龄血清浓度差异。结果398例入组病例中59例无抽搐,339例抽搐患儿,其中病毒性脑炎113例,23例化脓性脑膜炎,61例单纯性热性惊厥,74例癫痫,24例复杂性热性惊厥,电解质紊乱5例,急性腹泻并良性惊厥8例,捂热综合征2例,颅内占位2例,27例原因不明。不同病因、年龄NSE血清浓度差异无统计学意义;S100β血清浓度以化脓性脑膜炎组最高,各种病因之间差异有显著统计学意义(P=0.018)。其中,热性惊厥和复杂性热性惊厥组内不同年龄S100β血清浓度差异亦有显著统计学差异(P<0.01))。结论不同病因和不同年龄抽搐患儿中NSE血清浓度无明显差异;而S100β血清浓度有明显差异,且与年龄有关,可作为鉴别发热抽搐患儿病因临床指标之一。
Objective To explore the concentration changes of biomarkers in serum and the age-related characteristics in the children with convulsion caused by different diseases.Methods The S100β and NSE concentrations in serum from the children with convulsion caused by different diseases were detected within 24 hours of admission.Then compare the difference of the serum concentrations of the biomarkers in different causes groups and different age groups.Results In 398 cases,there were 59 cases without convulsion and 339 cases with convulsion.Among the latter,there were 113 cases of viral encephalitis,23 cases of bacterial meningitis,61 cases of simple febrile seizures(SFS) and 24 cases of complex febrile seizures(CFS),74 cases with epilepsy,electrolyte disorder in 5 cases,acute diarrhea with benign convulsion in 8 cases,muggy syndrome in 2 cases,2 case with intracranial space-occupying lesion and 27 cases of unknown cause,respectively.There were no significant difference for the NSE concentrations in different etiologies groups and different age groups.But there were significant difference for the S100β concentrations in different etiologies(P=0.018) and the S100β concentrations of children with bacterial meningitis were highest.In addition,the S100β concentrations were also significant difference in SFS intra-group and CFS intra-group(P<0.01).Conclusion There were no significant difference for the NSE concentrations in different causes groups and different age groups.But the significant difference existed in different groups for the S100β concentrations,and which were closely correlated with age.So it could be used as one of the clinical indicators to identify the etiologies of the children with convulsion caused by fever.
出处
《江西医药》
CAS
2013年第3期199-202,共4页
Jiangxi Medical Journal
