摘要
目的探讨神经生长因子(NGF)治疗对自发性脑出血患者血浆白细胞介素6(IL-6)的影响。方法选取357例自发性脑出血患者,按出血量多少分为小、中、大出血量三组,入院24h内采血,采用双抗体夹心酶联免疫吸附法(ELISA)检测血浆IL-6的量,并与正常健康体检患者做对照比较;三组患者均在使用NGF治疗前、后采血,检测IL-6的量。数据以x±s表示,多组间比较采用单因素方差分析,治疗前后比较采用配对资料t检验,检验水准α=0.05。结果小、中、大出血量IL-6含量分别为(108.62±14.22)、(142.51±23.43)和(183.78±43.82)μg/L,均显著高于正常对照(P<0.05),且与出血量的多少呈正相关,出血量越大,含量越高;经过NGF治疗后,三组IL-6的含量均下降,小、中、大出血量IL-6含量分别为(98.42±12.16)、(118.62±18.68)和(128.68±32.24)μg/L。与治疗前相比,下降的差异均有统计学意义(P<0.05)。结论血浆IL-6含量与脑出血量呈正相关,可以间接反映脑出血量的多少和脑损伤程度,脑出血量越大,损伤越重,血浆IL-6含量越高;NGF治疗能够降脑出血患者的IL-6,促进脑出血的恢复。
Objective To explore the influence of Neural Growth Factor(NGF)treatment on plasma Interleu- kin-6(IL-6)level in Cerebral Hemorrhage(CH)patients. Methods According to volume of hemorrhage, 357 CH patients were divided into small hemorrhage,medium hemorrhage,and large hemorrhage groups.Blood samples were collected within 24 hours.The Enzyme-Linked Immunosorbent Assay(ELISA) was used to test IL-6 level in plasma.The results were compared with samples from healthy people.IL-6 was collected for 3groups both before and after NGF treatment.x±s was used to show the distribution of the da- ta,one-way ANOVA was used to compare IL-6level among different groups,and paired t-test was used to compare IL-6level before and after treatment.Alpha is considered as 0.05. Results The IL-6levels of CH patients in different hemorrhage volume groups increased significantly as compared with the healthy control(108.62±14.22pg/ml,142.51 ±23.43pg/ml and 183.78±43.82pg/ml respectively in 3groups,P< 0.05).The lager hemorrhage volumes were the higher IL-6levels were.The IL-6levels after NGF treatment of CH patients in 3 different hemorrhage volume groups all decreased significantly(98.42 ±12.16pg/ml, 118.62±18.68pg/ml and 128.68±32.24pg/ml respectively in 3 groups)than before NGF treatment(P< 0.05). Conclusions IL-6 levels in plasma was close related to the volume of hemorrhage in CH patients, and it can be used as a director to predict the CH severity.The lager hemorrhage volumes were the higher IL- 6levels were.NGF treatment can effectively reduce the IL-6 level and promote recovery in CH patients.
出处
《慢性病学杂志》
2013年第10期736-738,共3页
Chronic Pathematology Journal
关键词
脑出血
神经生长因子
白细胞介素6
Cerebral Hemorrhage(CH)
Neural Growth Factor(NGF)
Interleukin-6(IL-6
