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危重糖尿病患者的强化血糖治疗

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摘要 1 重症糖尿病患者高血糖的危害 重症糖尿病患者处于严重应激状态,不论既往是否合并有糖尿病,都容易发生应激性高血糖,这是与炎症和神经内分泌紊乱导致的肝糖输出增多和胰岛素抵抗相关的[1]。不同血糖水平与感染性并发症的荟萃分析显示:血糖从8.0 mmol/L增加到8.9 mmol/L,感染的并发症增加42%,而从8.3 mmol/L增加到10.0 mmol/L,则感染性并发症可增加61%。控制应激性高血糖有助于下调炎症介质水平,改善代谢与免疫功能,从而改善重症患者的预后。有研究证实危重患者高血糖与增加患者死亡率相关[2]。与非糖尿病患者相比,危重的糖尿病患者可能存在免疫细胞功能异常,致感染增加[3]。同时合并的微血管及大血管并发症亦有可能增加死亡率。很多对于心脏外科手术和创伤糖尿病患者的研究表明,糖尿病是手术后出现并发症的危险因素,例如感染、延长重症监护室(ICU)住院时间等[4-6]。
作者 顾楠 郭晓蕙
出处 《中国医学前沿杂志(电子版)》 2012年第3期15-18,共4页 Chinese Journal of the Frontiers of Medical Science(Electronic Version)
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  • 1Dungan KM;Braithwaite SS;Preiser JC.Stress hyperglycaemia[J]The Lancet,2009(9677):1798-1807.
  • 2Krinsley JS.Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients[J]Mayo Clinic Proceedings,2003(12):1471-1478.
  • 3Alexiewicz JM;Kumar D;Smogorzewski M.Polymorphonuclear leukocytes in non-insulin-dependent diabetes mellitus:abnormalities in metabolism and function[J]Annals of Internal Medicine,1995(12):919-924.
  • 4Brown JR;Edwards FH;O'Connor GT.The diabetic disadvantage:historical outcomes measures in diabetic patients undergoing cardiac surgery-the pre-intravenous insulin era[J]Stmin Thorac Cardiovasc Surg,2006(04):281-288.
  • 5Bucerius J;Gummert JF;Walther T.Impact of diabetes mellitus on cardiac surgery outcome[J]Thorac Cardiovasc Strg,2003(01):11-16.
  • 6Abmad R;Cherry RA;Lendel I.Increased hospital morbidity among trauma patients with diabetes mellitus compared with age-and injury severity score-matched control subjects[J]Archives of Surgery,2007(07):613-618.
  • 7van den Berghe G;Wouters P;Weekers F.Intensive insulin therapy in critically ill patients[J]New England Journal of Medicine,2001(19):1359-1367.
  • 8Van den Berghe G;Wilmer A;Hermans G.Intensive insulin therapy in the medical ICU[J]New England Journal of Medicine,2006(05):449-461.
  • 9The NICE-SUGAR study investigators.Intensive versus conventional glucose control in critically ill patients[J]New England Journal of Medicine,2009(13):1283-1297.
  • 10Rady MY;Johnson DJ;Patel BM.Influence of individual characteristics on outcome of glycemic control in intensive care unit patients with or without diabetes mellitus[J]Mayo Clinic Proceedings,2005(12):1558-1567.

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