摘要
目的 探讨 97例乳腺浸润性导管癌的MVD、VEGF、CD和抑癌基因 p5 3的表达特征 ,判断其转移和生存时间的关系及临床应用意义。方法 应用免疫组化S P法和计算机图文分析处理系统 ,分析处理不同标记物的表达特征。结果 97例乳腺浸润性导管癌中 ,小于 5年组的MVD均值为 6 6 .0 5±2 3.86 ,大于 5年组的MVD均值为 5 4 .0 0± 2 3.4 7。小于 5年组中VEGF、CD、p5 3阳性表达及MVD均值高于大于 5年组 ,其P值均 <0 .0 1,0 .0 5及 0 .0 0 0 5 ,有显著性差异。结论 97例乳腺浸润导管癌中 ,5年内发生转移和死亡组 ,其VEGF、CD ,p5 3阳性表达和MVD高于 5年以上发生转移和死亡组。
Objective To inquire the feature of MVD,VEGF,CD and p53 expression of 97 invasive duct breast carcinoma cases,and to judge the relation ship between metastasis and survival rate the significance of clinical practice.Methods Immunohistochemical S P method and ressls were count by computer assisted analysis.Results The value of MVD was 66.05 ± 23.86 in less than five year group (Group A), 54.00 ± 23.47 in more than five year group (Group B). Group A,VEGF,CD,p53 positive expression and MVD were higher than group B. P < 0.01 , 0.05 and 0.0005 .Conclusion In 97 invasive duct breast carcinoma cases,if expression was positively in vascular endothelial growth factor,Cthepsin D and p53,was negatively microvascular density were higher,metastasis and death was easy in 5 year.
出处
《肿瘤防治研究》
CAS
CSCD
2004年第7期418-419,共2页
Cancer Research on Prevention and Treatment
关键词
乳腺癌
预后
免疫组织化学
微血管密度
Breast carcinoma
Prognosis
Immunohistochemistry
Microvascular density
