摘要
目的研究乙型肝炎病毒基因型与干扰素α疗效的关系。方法回顾性调查145例干扰素α治疗组和对照组患者的临床资料,并用聚合酶链反应-限制性酶切片段长度多态性方法(PCR-RFLP)分析其乙型肝炎病毒基因型。结果HBV优势基因是B(65.5%)和C(34.5%)型,B基因型95例,C基因型50例;对两基因型在治疗组和对照组的年龄、性别、ALT、HBV-DNA进行统计学分析,无显著性差异;治疗组65例患者接受干扰素α治疗,干扰素α治疗有效率在治疗组B、C两基因型中分别为77.3%、57.1%。结论B基因型HBV对干扰素α的有效应答率高于C型。
Objective To study the relationship between the HBV genotypes and efficacy of interferon alpha. Methods Clinical data from 145 patients in the original trial were analyzed. HBV genotype was determined by the restriction fragment length ploymorphism analysis. Results The majority of patients had HBV genotypes B (95 cases, 65.5%) and C (50 cases, 34.5%). The patients with CHB caused HBV B or C genotype had not any sighificant difference in age, sexual, serum ALT, HBV-DNA; Antiviral effective rates of HBV genotype B and C were 77.3% and 57.1% in 65 cases treated with interferon alpha (P<0.05). Conclusion HBV genotype B is associated with a higher effective rate of interferon alpha treated compared with genotype C.
出处
《实验与检验医学》
CAS
2007年第6期553-554,535,共3页
Experimental and Laboratory Medicine
关键词
肝炎病毒
乙型
干扰素A
基因型
治疗
Hepatitis B virus
Interferon alpha
Genotype
Therapy
