摘要
目的 研究尿毒症维持性血液透析患者血浆肉毒碱水平及静脉补充左旋肉毒碱(可益能)后的临床疗效。方法 选择本透析中心50例病情稳定、透析2年以上的维持性血液透析患者,应用酶法检测其透析前后的血浆肉毒碱水平后,将其随机分为两组,治疗组于每次透析结束时静脉注射左旋肉毒碱5ml(1克),对照组静脉注射等量的生理盐水,共应用2个月(26次透析)。复查两组患者血浆左旋肉毒碱水平及前白蛋白、转铁蛋白、白蛋白、血脂、血红蛋白浓度等,同时应用症状分级评分法观察两组用药前后体力、精神状态、食欲、恶心、呕吐、心功能、心悸、心律失常、肌肉疼痛、骨痛、透析低血压、肌肉痉孪、透析后虚弱无力持续时间等临床症状的变化情况和可能出现的不良反应。结果 ①两组患者存在明显的肉毒碱缺乏。②治疗组静脉补充可益能2月后,透析前后血浆肉毒碱水平均显著升高(P<0.01),透析后仍维持在正常值水平。对照组透析前后血浆肉毒碱水平无明显变化。③治疗组血浆前白蛋白、转铁蛋白、白蛋白较治疗前显著提高(P<0.05),干体重也显著增加(P<0.05)。对照组上述指标均无显著性变化。④治疗组血甘油三脂、总胆固醇、低密度脂蛋白与治疗前比较无显著性变化,但高密度脂蛋白较治疗前显著升高(P<0.05)。对照组血脂四项均无显著性变化。⑤?
Objective To evaluate the plasma camitine level and the effect of camitine supplementation on hemodial-ysis patients.Methods SO stable hemodialyaig patients were selected and divided into two groups,25 patients received intravenous L - camitine after each dialysis session in a dosage of Ig for two months,the other 25 patients received placebo .Plasma camitine level,pre- albumin ,albumin,transferrin,blood lipid ,hemoglobin and clinical symptoms were studied .Results Hie plasma camitine level were lower than normal in hemodialysis patients.After L- camitine supplementation,plasma camitine,pre-albumin,albumin,transferrin,HDL were significantly elevated (P< 0.05),Physical and mental status,appetite,arrhythmia,dialysis tolerance were improved in the treated groups.Hie parameters were not significantly changed in placebo groups.Conctuskm L - camitine supplementation can treat the camitine deficiency in hemodialysis patients effectively.
出处
《中国血液净化》
2002年第10期18-21,共4页
Chinese Journal of Blood Purification
