摘要
目的:探讨南充市原发性肝癌(hepatocellular carcinoma,HCC)的危险因素,为我市预防肝癌的发生提供科学依据。方法:应用病例对照研究的方法,对南充市新诊断的226例原发性肝癌患者进行1∶1配对,通过条件Logist ic回归单因素和多因素分析筛选肝癌的主要危险因素。结果:单因素条件logist ic回归分析发现有22个因素与肝癌的发生有关;多因素条件logistic回归分析发现有10个主要危险因素与肝癌的发生有关,即HbsAg阳性(OR=5.83,95%C.I.1.23-2.78)、慢性乙肝病史(OR=4.92,95%C.I.3.28-7.03)、肝硬化(OR=4.21,95%C.I.4.75-7.23)、吸烟(OR=2.87,95%C.I.1.31-4.72)、吸烟量≥20包*年(OR=3.89,95%C.I.2.97-4.67)、饮酒(OR=3.03,95%C.I.1.23-5.21)、饮酒≥250g/日(OR=3.91,95%C.I.1.61-5.39)、饮地面水(OR=2.67,95%C.I.1.28-4.33)、肿瘤家族史(OR=2.98,95%C.I.1.84-3.63)、精神压抑(OR=1.84,95%C.I.1.02-3.81)。常吃腌菜、酸菜(OR=1.24,95%C.I.0.68-2.64)是一个可能的危险因素,尚待进一步探讨。结论:肝癌的发生是多种因素综合作用的结果,控制危险因素可减少肝癌的发病率。
Objective:To explore risk factors of primary hepatocellular carcinoma(HCC)in Nanchong so as to provide a scientific basis for effective prevention of HCC.Methods:226 newly diagnosed primary hepatocellular carcinoma cases and equal number of controls were enrolled in the study.Statistical analysis of single-factor and multivariate conditional Logistic regression was performed to screen the risk factors of HCC.Results:During the single-factor analysis,22 exposure factors were identified as aetiological factor...
出处
《华西医学》
CAS
2008年第6期1345-1347,共3页
West China Medical Journal
关键词
原发性肝癌
危险因素
病例对照研究
primary hepatocellular carcinoma
risk factors
case-control study
