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冠状动脉内支架术前后血浆C-反应蛋白水平的变化

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摘要 目的观察不同类型心绞痛患者支架术前后血浆 C-反应蛋白浓度的变化及其意义。方法选择15例冠心病进行支架术的患者(稳定性心绞痛组13例;不稳定性心绞痛组38例)作为研究对象,同时选择一组同期进行冠脉造影的患者为对照组。分别于支架术或造影术前当天早晨、术后48h 采集静脉血进行血浆 C-反应蛋白。结果术前,稳定性心绞痛组与冠脉造影组比较,C-反应蛋白水平无显著差异;不稳定性心绞痛组 Braunwald Ⅱ、Ⅲ级与稳定性心绞痛组、冠脉造影组比较 C-反应蛋白水平均有显著性升高,P 值均小于0.05。但不稳定性心绞痛各亚组间 C-反应蛋白差异无显著性。术后,冠脉造影组 C-反应蛋白浓度与造影前比较无显著差异(P>0.05)。但观察组稳定性心绞痛组、不稳定性心绞痛各亚组术后 C-反应蛋白均显著升高,且随不稳定性心绞痛临床分级增加升高越显著,各组间比较差异均有显著性意义。复杂病变型与简单病变型比较术后 C-反应蛋白升高有显著意义(P<0.01)。观察组术后 C-反应蛋白浓度与术前无显著直线相关(r=0.32,P>0.05)。结论冠状动脉支架术增加不同类型心绞痛患者血浆 C-反应蛋白水平;不稳定性心绞痛临床分级越重,术后 C-反应蛋白水平升高越明显,提示 C-反应蛋白水平可作为冠状动脉病变不稳定性的预测指标。
出处 《航空军医》 2005年第5期202-204,共3页 Flight Surgeon
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