摘要
目的:了解转移抑制基因(nm23-H1)和原癌基因(cerbB-2)在食管鳞癌表达与肿瘤临床、病理各指标间的关系。方法:用免疫组化的方法分析两个基因在91例食管癌(鳞癌84例,腺癌3例,未分化癌4例)的表达。结果:nm23-H1和CerbB-2染色均定位于细胞浆,两者均与淋巴结转移、预后有显著相关性。在无淋巴结转移组,CerbB-2蛋白表达亦和预后有显著负相关。结论:认为nm23-H1高表达或CerbB-2低表达者,淋巴转移率低,术后生存率高,预后较好,CerbB-2可作为一个独立的预后指标,无论有无淋巴结转移,CerbB-2蛋白高表达预后均差。
Objective:To study the relationship between expression of nm23-H1 and CerbB-2 as well prognosis in esophageal carcinoma.Methods:expression of gene nm23-H1 and CerbB-2 were done by immunohistochemistry in 91 cases of esophageal carcinoma(84 cases of squamous carcinoma,3 cases of adenocarcinoma and 4 cases of undifferentiated small cell carcinoma).Results:Low rate of lymph node metastasis and high long term survival rate were found in the group with high expression of nm23-H1 or low expression of CerbB-2.In negative lymph node metastasis group,the expression of cerbB-2 was related to negative prognosis.Conclusions:There is a good prognosis if high nm23-H1 expression and low CerbB-2 expression were found in patients with esophageal carcinoma;and CerbB-2 can be an independent index as prognosis evaluation.
出处
《青海医药杂志》
2007年第5期9-11,共3页
Qinghai Medical Journal
