摘要
目的评价经皮椎体后凸成形术(PKP)治疗原发性肝癌脊柱转移的早期临床疗效。方法收集海军军医大学第三附属医院2016—2021年期间PKP治疗的原发性肝癌脊柱转移患者87例资料。对87例患者入院当天及术后7天、1个月、3个月Oswestry功能障碍指数(ODI)、疼痛视觉模拟评分(VAS)、肿瘤骨转移患者生存质量表(QLQ-BM22)进行评估。结果87例原发性肝癌脊柱转移患者均顺利完成PKP手术并在术后第7天、1个月、3个月获得随访。PKP术后第7天、1个月、3个月患者的ODI评分、VAS评分、QLQ-BM22评分均较术前降低(均P<0.001),分别为第7天33.65∶79.28、2.51∶6.64、40.72∶69.17,1个月29.28∶79.28、2.37∶6.64、39.93∶69.17,3个月36.77∶79.28、2.68∶6.64、41.12∶69.17。结论PKP对原发性肝癌伴椎体破坏的、无椎管内占位脊柱转移患者能够减轻疼痛和稳定椎体,具有可行性和安全性,是一项可以明显提高患者生存质量的微创技术。
Objective To evaluate the early clinical efficacy of percutaneous kyphoplasty(PKP)for the treatment of primary liver cancer with spinal metastasis.Methods 87 patients with primary liver cancer with spinal metastasis underwent PKP in The Third Affiliated Hospital of Naval Military Medical University from January 2016 to June 2021.Oswestry Disability Index(ODI),Visual Analogue Scale of pain(VAS)and EORTC QLQ-BM22(Europe Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Bone Metastases 22)were assessed for the patients with bone metastases on the day of admission,7 days,1 month and 3 months after surgery.Results A total of 87 patients with primary liver cancer with spinal metastases successfully underwent PKP and were followed up on 7 days,1 month and 3 months after surgery.The ODI,VAS and QLQ-BM22 scores of PKP patients on 7 days after treatment,1 month and 3 months after surgery were lower than those before surgery,and the differences were statistically significant(P<0.001).The ODI,VAS,and QLQ-BM22 scores were all decreased on 7 days,1 month,and 3 months after PKP(P<0.001),33.65 vs 79.28,2.51 vs 6.64,40.72 vs 69.17,respectively on 7 days,29.28 vs 79.28,2.37 vs 6.64,39.93 vs 69.17 on 1 Month,and 36.77 vs 79.28,2.68 vs 6.64,41.12 vs 69.17 on 3 Months.Conclusions PKP is a minimally invasive technique.It could relieve pain and stabilize vertebral body.It is feasible and safe.It could significantly improve the quality of life for patients with primary liver cancer with vertebral destruction and without intraspinal space-occupying.
作者
陈凤梅
汪秉轩
张志文
刘丽
许常利
唐飞扬
蒋帅
Chen Fengmei;Wang Bingxuan;Zhang Zhiwen;Liu Li;Xu Changli;Tang Feiyang;Jiang Shuai(Department of Orthopaedics,the Third Affiliated Hospital of Naval Medical University,Shanghai 201805,China)
出处
《中华转移性肿瘤杂志》
2022年第4期306-311,共6页
Chinese Journal of Metastatic Cancer
基金
上海市嘉定区卫计委科研课题(2019-KY-19)
关键词
原发性肝癌
脊柱转移
经皮椎体后凸成形术
治疗结果
Primary liver cancer
Spinal metastasis
Percutaneous Kyphoplasty
Treatment outcome
