摘要
目的研究胃癌高危人群血清胃泌素(G-17)的分泌水平和幽门螺杆菌(Hp)感染情况.方法在山东省临朐县对胃癌高发现场的242名村民进行13C-尿素呼吸试验检测Hp的感染情况,对血清样品中的胃泌素水平进行定量测试.结果Hp的总感染率53.72%,其中男性Hp感染率为58.56%,女性Hp感染率为49.62%,两者之间差异无统计学意义(x^(2)=1.932,P=0.165).不同年龄段之间的Hp感染率差异也无统计学意义(x^(2)=4.185,P=0.123).血清中G-17的平均总水平为(24.43±25.46)pmol/L,其中女性为(29.87±28.18)pmol/L,男性为(18.01±20.11)pmol/L;女性的平均水平高于男性(Z=-3.618,P<0.001).而在年龄分布上并无明显上升或下降趋势(H=1.948,P=0.378).血清G-17水平在Hp阴性者为(35.50±30.92)pmol/L,阳性者为(14.90±13.79)pmol/L,两者之间差异有统计学意义(Z=5.368,P=0.0001).结论胃癌高发区临朐县的受检人群中,Hp阴性者的G-17分泌水平要高于Hp感染者.不同性别的G-17分泌水平不同,但不同年龄的G-17水平并无差异.
Objective To investigate the associations of serum gastrin-17(C-17)concentration with helicobacter pylori(Hp)infection.Methods A"C-urea breath and ELISA test to detemine the Helicobacter pylori status and to detect the serum gastrin concentration was conducted in 242 villagers in Linqu of Shandong Province,a high gastric cancer prevalence area in China.Results Of 242 subjects,65 of 111 were found Hp-positive in males(58.56%),compared with 65 of 131 in females(49.62%)(X^(2)=1.932,P=0.165).The statistical difference was not observed among different age groups(X^(2)=4.185,P=0.123).The average level of G-17 among 242 subjects was(24.43±25.46)pmol/L and it W88 statistically higher in females(29.87±28.18)pmol/L than that in males(18.01±20.11)pmol/L(Z=-3.618,P<0.001).However,there was no statistical difference found among age groups(x=1.948,P=0.378).The G-17 level in Hp-negative group(35.50±30.92)pmol/L was observed significantly higher than in Hp-positive group(14.90±13.79)pmol/L(Z=5.368,P=0.0001).Conclusion The G-17 concentration was found higher in Hp-negative subjects than in Hp-positive subjects,and higher in female than in male,but no diference was found among age groups.
作者
聂晓瑞
周彤
潘凯枫
李文庆
冯国双
张阳
张联
游伟程
NIE Xiao-rui;ZHOU Tong;PAN Kai-feng;LI Wen-qing;FENG Guo-shuang;ZHANG Yang;ZHANG Lian;YOU Wei-cheng(Peking Uniwersity School of Oncology,and Bejing Intitute for Cancer Rssearch,Bejing 100036,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2007年第S01期87-89,共3页
Chinese Journal of Preventive Medicine
关键词
螺杆菌
幽门
胃泌素类
胃肿瘤
Helicobacter pylori
Gastrins
Stomach Neoplasms
