摘要
目的了解广西南部农村人群各种肝病的患病状况及其流行特点.方法调查广西南部农村20~55岁男女人群,共调查15701名.应用酶联免疫试验(EIA)检测血清HBsAg和AFP,并对AFP阳性者应用放射免疫法(RIA)定量测定;采用改良赖氏法检测血清丙氨酸转氨酶(ALT);采用Siemens-Adam黑白B超机对肝脏进行检查.结果该人群HBsAg阳性率为17.8%(2800/15701),乙肝、肝硬变、肝癌、肝吸虫、脂肪肝和酒精肝患病率分别为1.1%(173/15701)、0.4%(63/15701)、299.3/10万(47/15701)、6.6%(1036/15701)、4.8%(754/15701)和0.3%(47/15701);HBsAg阳性率和乙肝、肝硬变、肝癌、肝吸虫以及脂肪肝患病率均为男性显著高于女性,差异均有统计学意义(X^(2)值在5.98~394.78之间,P值均<0.01);肝血管瘤和肝囊肿患病率男女之间无差别;肝内胆管结石患病率女性高于男性,差异有统计学意义(X^(2)值=30.80,P<0.01).HBsAg阳性率和乙肝、肝吸虫患病率均随着年龄的增长而下降趋势;肝硬变、肝癌、脂肪肝、酒精肝、肝血管瘤、肝囊肿和肝内胆管结石患病率均随着年龄的增长而呈升高趋势.结论广西南部农村是肝病流行严重地区,尤其男性成年人群为肝病高危人群.
Objective To study the epidemiological characteristics of liver diseases in a rural population in Southerm Guangxi,China Methods The enzyme immunssays W88 used to detect of HBsAg and AFP.AFP positive serum samples were further examined for concentration of AFP by using a radio immunoassays.Liver morphological changes were measured with ultrasonography of type B.Results The positive rates of HBsAg in the studied population was 17.8%(2800/15701).The prevalence rates of viral hepititis B,cirhosis,primary liver cancer,clonorchisasis,ftty liver disease,alcoholic liver disease were 1.1%(173/15701),0.4%(63/15701),299.3 per 100000(47/15701),6.6%(1036/15701),4.8%(754/15701)and 0.3%(47/15701),espectively.The positive rates of HBsAg and the prevalence rate of viral hepatitis B,cirhosis,primary liver cancer,clonorchissis,fatty liver disease in male were sigificantly higher as compared with those in female(5.98≤x≤394.78,P<0.01).No iference W88 observed in the prevalence rates of liver cavermoushemangloma and hepatic cysts between male and female.The prevalence rates of intrahepatic bile duct stones was significantly higher in female than in male(X^(2)=30.80,P<0.01).The positive rates of HBsAg and the prevalence rates of viral hepititis B and clonorchisasis were decreased with age.But the prevalence rates of cirhosis,primary liver cancer,fatty liver disease,alcoholic liver disease,liver cavermoushemangloma,hepatic cysts and intrahepatic bile duct stones were incressed with age.Conclusion The rural areas in the southem Guangxi are high prevalence regions of liver ilness,and the male resident are even at high risk.
作者
黄天壬
余家华
利基林
张振权
邓伟
张春燕
赵盛发
HUANG Tian-ren;YU Jia-hua;LI Ji-lin;ZHANG Zhen-quan;DENG Wei;ZHANG Chun-yan;ZHAO Sheng-fa(Guangxi Cancer Institute,Nnanning 530021,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2007年第S01期123-126,共4页
Chinese Journal of Preventive Medicine
基金
广西科学研究与技术开发计划项目(桂科攻0632007-10)
关键词
横断面研究
肝疾病
农村卫生
流行病学研究
Cross-sectional studies
Liver diseases
Rural health
Epidemiologic studies
