摘要
目的:比较阿尔茨海默病(Alzheimer’s disease,AD)患者和认知正常老年人的自主神经功能障碍特点,了解AD患者自主神经功能障碍的发生率及症状特点。方法:选取65岁及以上的很可能AD患者188例和来源于社区研究的认知功能正常老年人860例,对他们进行基本信息搜集,神经精神量表和自主神经功能障碍量表评估,比较AD患者和认知正常老年人的自主神经功能障碍的发生率及症状特点。结果:AD组的自主神经功能障碍发生率为21.3%,认知正常组的自主神经功能障碍发生率为11.2%,二者有统计学差异(P<0.05)。两组发生率最高的症状均为便秘和尿频、尿急、尿不尽。AD组的便秘发生率高于认知正常组,具有统计学差异(P<0.05)。心血管疾病是自主神经功能障碍发生的独立危险因素。结论:AD患者的自主神经功能障碍发生率高于认知正常人群,其中以便秘症状最为明显。
Objective To compare the characteristics of autonomic dysfunction in elderly population with Alzheimer’s disease(AD)and with normal cognitive function,and find out the prevalence and symptom characteristics of autonomic dysfunction in elderly population with AD.Methods 188 elderly people over 65 years old who were diagnosed as probably AD and 860 elderly people over 65 years old with normal cognitive function from a community study were included finally.Basic information collection,neuropsychology scale assessment and autonomic dysfunction scale assessment were performed on all the included subjects to compare the prevalence and symptom characteristics of autonomic dysfunction.Results The prevalence of autonomic dysfunction in the AD group was 21.3%,and the prevalence of autonomic dysfunction in the normal cognitive function group was 11.2%.There was significant difference between the two groups(P<0.05).The symptoms that occurred mostly in both groups were constipation and urinary frequency,urinary urgency,urinary insufficiency.The prevalence of constipation in the AD group was higher than that in the normal cognitive function group,and the difference was statistically significant(P<0.05).Multivariate analysis showed that the cardiovascular disease was the risk factor for autonomic dysfunction.Conclusion The prevalence of autonomic dysfunction in the AD group was higher than that in the normal cognitive function group.The symptoms with significant difference was constipation.
作者
杜晓姗
刘帅
胡文政
甘景环
朱涵
石志鸿
纪勇
Du Xiao-shan;Liu Shuai;Hu Wen-zheng;Gan Jing-huan;Zhu Han;Shi Zhi-hong;Ji Yong(Graduate School of Tianjin Medical University;Tianjin Huanhu Hospital;Department of Neurology,Beijing Tiantan Hospital,Capital Medical University)
出处
《阿尔茨海默病及相关病杂志》
2019年第4期510-516,共7页
Chinese Journal of Alzheimer's Disease and Related Disorders
基金
国家自然科学基金(81571057)
天津市科技计划项目(16ZXMJSY00010).
