期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

130例三阳性乳腺癌的临床病理特征及预后 被引量：1

The clinicopathological characteristics and prognosis of 130 cases of triple-positive breast cancer
暂未订购
导出
摘要 目的:探讨三阳性乳腺癌(triple-positive breast cancer,TPBC)患者的临床病理特征及预后。方法:收集2010年9月至2015年9月我院收治的TPBC患者130例,对其临床病理资料进行回顾性分析。结果:研究中,TPBC患者共130例,占所有乳腺癌患者的13.10%。其中,63.08%为超重/肥胖患者(BMI≥24),52.31%的患者合并有慢性病。患者最常见的首诊症状为发现乳房肿块(80例,占61.54%),而非疼痛(10例,占7.69%)。病灶的位置以右侧多见(75例,占57.69%),最常见的部位为外上象限(58例,占44.62%)。最常见病理学类型为浸润性导管癌(104例,占80.00%)。随访结果表明,局部复发率为9.23%(12例),远处转移率为26.92%(35例)。最常见的转移部位为骨(24例,占68.57%),其次为肺(18例,占51.43%)。结论:TPBC患者的预后较差,容易发生远处转移,且有早期转移倾向,因此迫切需要对TPBC进行全面的研究,更深入的了解TPBC的异质性。 Objective:To investigate the clinicopathological characteristics and prognosis of triple-positive breast cancer(TPBC).Methods:The clinicopathological data of 130 patients with TPBC from September 2010 to September 2015 were retrospectively analyzed.Results:In our study,130 TPBC patients account for 13.10%of all breast cancers.63.08%of TPBC are overweight/obese patients(BMI≥24),and 52.31%of TPBC have chronic diseases.The most common complaint of TPBC patients was the presence of a breast mass(n=80,61.54%)rather than pain(10 cases,7.69%).The tumor was more common on the right side(n=75,57.69%).The most common site was the upper outer quadrant(n=58,44.62%).The most common pathological type is invasive ductal carcinoma(n=104,80.00%).The follow-up results showed that the local-recurrence rate was 9.23%(12 cases),and the distant-metastasis rate was 26.92%(35 cases).The site of most common metastasis is bone(n=24,68.57%),followed by lung(n=18,51.43%).Conclusions:The prognosis of TPBC patients is poor.TPBC is prone to occur distant metastasis.There is a tendency for early metastasis.It is necessary to comprehensively study on TPBC.
作者 李玉龙 殷世明 彭德峰 陈春春 安程程 马小开 朱金海 董慧明 LI Yulong;YIN Shiming;PENG Defeng;CHEN Chunchun;AN Chengcheng;MA Xiaokai;ZHU Jinhai;DONG Huiming(First Affiliated Hospital of Bengbu Medical College,Department of Breast and Nail Surgery,Bengbu 233004,China)
机构地区 蚌埠医学院第一附属医院甲乳外科
出处 《包头医学院学报》 CAS 2021年第7期9-12,54,共5页 Journal of Baotou Medical College
基金 2020年国家级大学生创新创业训练计划项目(202010367020) 安徽省教育厅自然科学研究项目(KJ2015B097by)
关键词 乳腺癌 三阳性 临床病理特征 预后 breast cancer triple-positive clinicopathological characteristics prognosis
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献1

二级参考文献15

  • 1Perou C M, Sorlie T, Eisen M B, et al. Molecular portraits of hu- man breast tumour[ J ]. Nature, 2000,406 (6797) :747-52.
  • 2Arpino G, Wiechmann L, Osborne C K, et al. Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family : and clinical implications for endocrine thera- py resistance[J]. Endocr Rev, 2008,29(2) :217-33.
  • 3Prat A, Baselga J. The role of hormonal therapy in the manage-ment of hormonal-receptor- positive breast cancer with co-expres- sion of HER2[J]. Nat Clin Praet Oncol, 2008,5(9) :531 -42.
  • 4Geyer F C, Rodrigues D N, Weigelt B, et al. Molecular classifi- cation of estrogen receptor-positive / luminal breast cancers [ J ]. Adv Anat Pathol, 2012,19( 1 ) :39 - 53.
  • 5Wolff A C, Hammond M E, Hicks D G, et al. Recommendations for human epidermal growth factor receptor 2 testing in breast canc- er: American society of clinical oncology/college of American pa- thologists clinical practice guideline update [ J ]. J Clin Oncol, 2013,31 (31) :3997 -4013.
  • 6Cheang M C, Chia S K, Voduc D, et al. Ki67 index, HER2 sta- tus, and prognosis of patients with luminal B breast cancer[ J]. J Natl Cancer Inst, 2009,101 (10) :736 - 50.
  • 7Van Calster B, Vanden Bempt I, Drijkoningen M, et al. Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive[ J]. Breast Cancer Res Treat, 2009,113 : 181 -7.
  • 8Saal L H, Holm K, Manrer M, et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma[ J ]. Cancer Res, 2005,65(7) :2554 -9.
  • 9Hayashi N, Niikura N, Yamauchi H, et al. Adding hormonal therapy to chemotherapy and trastuzumab improves prognosis in pa- tients with hormone receptor-positive and human epidermal growth factor receptor 2-positive primary breast cancer[J], Breast Cancer Res Treat, 2013,137(2) :523 -31.
  • 10Bartlett J M, Ellis I O, Dowsett M, et al. Human epidermal growth factor receptor 2 correlates with lymph node involvement in patients with estrogen receptor (ER) negative, but with grade in those with ER-positive early-stage breast cancer suitable for cyto- toxic chemotherapy [ J ]. J Clin Oncol, 2007,25 (28) :4423 - 30.

共引文献3

同被引文献2

引证文献1

包头医学院学报
2021年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部