摘要
目的评价康莱特注射液联合化疗对晚期(Ⅲ~Ⅳ期)非小细胞肺癌(non-small cell lung cancer,NSCLC)患者免疫功能的影响。方法按照循证医学的要求,运用计算机检索中国知网(China National Knowledge Infrastructure,CNKI)、万方数据库、中国科技期刊数据库、中国生物医学文献数据库、Medline、PubMed、Cochrane Library、EMBASE以及Clinical Trials等,各数据库检索时间均从建库起至2019-01月,同时检索相关的参考文献。纳入康莱特注射液联合化疗药物治疗NSCLC的随机对照试验(randomized controlled trials,RCTs),由2名研究员分别独立提取数据和进行文献质量评价,并用RevMan 5.3软件进行meta分析。结果共检索出符合纳入标准的RCTs 19篇,包括患者1492例。Meta分析结果显示:康莱特注射液联合化疗组相较于单纯化疗组提高了近期疗效[OR=1.89,95%CI:1.46~2.44,P<0.00001]。两组的CD3+,CD4+,CD8+,IgA,IgG,IgM水平在治疗前差异无统计学意义(P>0.05),而治疗后CD3+,CD4+,IgA,IgG差异有统计学意义(P<0.05)。结论康莱特注射液联合化疗提高了NSCLC患者的免疫功能及近期疗效,但由于所纳入研究的质量不高,仍需进行方法学严谨的RCTs验证此结果。
Objective To system assess the effect of Kanglaite injection combined with chemotherapy on immune function in patients with advanced non-small cell lung cancer(NSCLC).Methods According to the requirements of evidence-based medicine,the relevant literatures were searched by the China National Knowledge Infrastructure,Wanfang Database,Database of Chinese Sci-tech Periodicals,China Biomedical Literature Database,Medline,PubMed,Cochrane Library,EMBASE and Clinical Trials from the establishment of the database to January 2019.Randomized controlled trials(RCTs)of Kanglaite injection combined with chemotherapy in the treatment of NSCLC were included,and the data and quality of the literatures were extracted and evaluated by two researchers,then the meta-analysis was performed using RevMan 5.3 software.Results A total of 19 RCTs were retrieved,including 1492 patients.Meta-analysis showed that Kanglaite injection combined with chemotherapy group improved the short-term curative effect compared with the simple chemotherapy group[OR=1.89,95%CI:1.46~2.44,P<0.00001].There was no significant difference of CD3+,CD4+,CD8+,IgA,IgG,IgM levels between the two groups before treatment(P>0.05),while the CD3+,CD4+,IgA,IgG levels between the two groups were significant differences after treatment(P<0.05).Conclusion Kanglaite injection combined with chemotherapy can improve the immune function and shorten efficacy of NSCLC patients.However,due to the low quality of the included studies,rigorous RCTs are still needed to verify the results.
作者
张曙红
王鹤玲
饶智国
ZHANG Shuhong;WANG Heling;RAO Zhiguo(Graduate School of Hubei University of Chinese Medicine,Wuhan Hubei 430070,China)
出处
《华南国防医学杂志》
CAS
2020年第7期498-504,共7页
Military Medical Journal of South China
关键词
非小细胞肺癌
免疫功能
康莱特注射液
化疗
META分析
Non-small cell lung cancer
Immune function
Kanglaite injection
Chemotherapy
Meta analysis
