摘要
目的分析妊娠期高血压疾病(HDP)患者多项血生化指标水平变化及新生儿出生体重差异。方法随机选取2018年6月至2019年3月郑州大学第三附属医院确诊并分娩的HDP孕妇678名作为研究组,选取该院同期分娩的700名正常妊娠妇女作为对照组。按照患病严重程度将HDP患者分为妊娠期高血压、轻度子痫前期、重度子痫前期三个亚组,比较各亚组患者血生化指标水平及新生儿出生体重。结果HDP组患者血液中血小板数目(PLT)、血红蛋白(HB)和总蛋白(TP)、红细胞压积(HCT)、血清游离雌三醇中位数倍数(u E_(3)MOM)值均低于对照组,且随病情严重程度加重而递减(P<0.05);而血浆D-二聚体、谷丙转氨酶(ALT)、谷草转氨酶(AST)值在HDP组中明显高于对照组,且随病情严重程度加重含量逐渐增加(P<0.05);各亚组间红细胞分布宽度变异系数(RDW-CV)差异无统计学意义(P>0.05);新生儿出生体重在HDP组明显低于对照组,且随病情严重程度加重呈下降趋势(P<0.05)。结论HDP患者多项血生化指标水平较正常孕妇存在较大差异,可作为判断病情严重程度及评估疾病进展的重要辅助指标;且HDP是新生儿出生体重的重要影响因素,应积极治疗阻断疾病进展,选择合适的分娩时机,降低HDP对新生儿的不良影响。
Objective To analyze the changes of blood biochemical indexes and the difference of neonatal birth weight in patients with hypertensive disorder of pregnancy(HDP)with different severity.Methods 678 pregnant women who were diagnosed with HDP and delivered in the Third Affiliated Hospital of Zhengzhou University from June 2018 to March 2019 and 700 normal pregnant women who delivered in the hospital during the same period were selected as study group and control group,respectively.In terms of severity,pregnant women with HDP were divided into three sub-groups:gestational hypertension,mild preeclampsia,and severe preeclampsia.Blood biochemical indexes and neonatal birth weight in pregnant women in each group were compared.Results Platelet count(PLT),hemoglobin(HB)and protein(TP),hematocrit(HCT),median multiple of serum free estriol(u E_(3)MOM)level in study group were significantly lower than those in control group,and they decreased with the severity of the disease(P<0.05);the values of D-dimer,alanine aminotransferase(ALT),aspartate aminotransferase(AST)in study group were significantly higher than those in control group,and the content gradually increased with the severity of the disease(P<0.05);there was no statistically significant difference in RDW-CV among the sub-groups(P>0.05);the birth weight of neonates in study group was significantly lower than that in control group,and showed a decreasing trend with the severity of the disease(P<0.05).Conclusion There are significant differences in the blood biochemical indexes in pregnant women with HDP compared with normal pregnant women,which can be used as an important auxiliary index to judge the severity of the disease and evaluate the disease progression.In addition,HDP is an important factor affecting neonatal birth weight,and active treatment should be taken to block the progression of the disease,and appropriate delivery timing should be selected to reduce the adverse effects of the disease on newborn.
作者
赵悦淑
王梦玲
王蕊
于硕
张小安
崔世红
ZHAO YueShu;WANG MengLing;YU Shuo;WANG Rui;ZHANG Xiaoan;CUI ShiHong(Department of Gynecology and Obstetrics,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China;Pengcheng Laboratory,Shenzhen 51800,Guangzhou)
出处
《河南预防医学杂志》
2021年第7期549-552,共4页
Henan Journal of Preventive Medicine
