摘要
目的比较健康老年人(healthy elderly,HE)、轻度认识障碍(mild cognitive impairment,MCI)老年患者、阿尔茨海默病(alzheimer disease,AD)老年患者在后扣带回磁共振成像T1WI序列图像纹理特征差异,为临床诊断提供参考。方法选取2015年1月-2017年8月阿尔茨海默病神经影像学中心数据库168例健康老年人、233例轻度认识障碍老年患者及101例阿尔茨海默病老年患者T1WI图像进行后扣带回纹理特征分析,比较三组间角二阶矩、对比度、自相关、逆差距、熵5个纹理特征参数的差异,同时用多元有序logistic回归分析法建立诊断模型,绘制受试者工作特征曲线评价模型预测能力。结果HE与MCI、AD三组之间在角二阶矩(P=0.000)、对比度(P=0.001)、逆差距(P=0.000)和熵(P=0.000)这4个参数上的差异均有统计学意义,但自相关(P=0.095)不存在统计学差异;有序多分类logistic回归分析提示逆差距和简易智力状态检查量表评分可以作为鉴别三者的变量。基于logistic回归建立的诊断分析模型的受试者工作特征曲线下面积分别为0.894(HE vsMCI-AD)、0.995(AD vs HE-MCI)。结论基于磁共振成像T1WI序列图像的后扣带回纹理特征分析在HE、MCI与AD患者鉴别中有一定价值。
Objective To compare the difference of the texture features of the posterior cingulate on T1WI among healthy elderly(HE),the elderly patients with mild cognitive impairment(MCI)and the elderly patients with Alzheimer disease(AD).Methods Theimaging data were obtained from Alzheimer’s disease neuroimaging initiative(ADNI)database from January 2015 to August 2017.The texture analysis were performed based on T1WI among 168 HEs,233 patients with MCI and 101 patients with AD,and the texture parameters included Angular Second Moment(ASM),Contrast,Correlation,Inverse Difference Moment(IDM),and Entropy.The difference in texture parameter was compared between the three groups,and regression model was established by oridinal logistic regression analysis.Receiver operation characteristic(ROC)curve was used to evaluate the diagnostic efficacy.Results There were significant differences in the texture ASM,Contrast,IDM and Entropy among HE,MCI and AD(PASM=0.000,Pcontrast=0.001,PIDM=0.000 and Pentropy=0.000,respectively),while the texture Correlation presented no significant difference among the three goups(Pcorrelation=0.095).Oridinal Logistic regression analysis demonstrated that the texture IDM and Mini-mental State Examination score could be considered as the specific variables for the diagnosis of AD from HE and MCI.The area under the curve for equations established based on logistic regression was 0.894(HE vs MCI-AD)and 0.995(AD vs HE-MCI).Conclusion The texture analysis of the posterior cingulate on T1WI could primarily be used to differentiate HE,MCI and AD.
作者
王波涛
招云春
陈志晔
WANG Botao;ZHAO Yunchun;CHEN Zhiye(Department of Radiology,Hainan Hospital of Chinese PLA General Hospital,Sanya 572013,Hainan Province,China;Cadre Ward,Chinese PLA 920 Hospital,Kunming 650032,Yunnan Province,China;Department of Radiology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)
出处
《解放军医学院学报》
CAS
2020年第7期675-678,682,共5页
Academic Journal of Chinese PLA Medical School
关键词
轻度认识障碍
阿尔茨海默病
纹理分析
磁共振成像
鉴别诊断
mild cognitive impairment
Alzheimer disease
texture analysis
magnetic resonance imaging
differential diagnosis
