摘要
免疫耐受是器官移植临床研究的终极目标,是改善移植患者预后生存的关键。调节性T细胞(regulatory T cells,Tregs)在诱导免疫耐受过程中发挥着重要作用,如何诱导供体产生特异性Tregs是诱导免疫耐受突破的关键。尽管近20年来已经证实CD8^+Tregs在移植诱导免疫耐受中发挥重要的作用,但其特性仍然存在很大的争议。本文拟对CD8^+Tregs移植免疫耐受研究进展作一综述,探讨其在诱导肝移植免疫耐受中的潜力。
Immune tolerance is the ultimate goal of research in organ transplantation,and it is the key to improve the prognosis and survival of transplant patients.Regulatory T cells(Tregs)are of great importance in the process of inducing immune tolerance.How to induce donor-specific Tregs is the key to the breakthrough of immune tolerance.Although it has been confirmed that CD8^+Tregs play a very important role in inducing immune tolerance in the past 20 years,its characteristics are still controversial.The purpose of this article is to review the research advances in immune tolerance induced by CD8^+Tregs in order to explore its potential of inducing immune tolerance in liver transplantation.
作者
赵阳
周林
贺强
ZHAO Yang;ZHOU Lin;HE Qiang(Department of Hepatobiliary,Pancreatic and Splenic Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)
出处
《解放军医学院学报》
CAS
2020年第7期743-745,751,共4页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金面上项目(81571825)
