摘要
目的观察加味黄连温胆汤治疗H型高血压的血压、Hcy和胰岛素抵抗的临床疗效,探索其疗效其安全性。方法选取黑龙江中医药大学第一附属医院心内科门诊部符合H型高血压患者总计60例,随机分为对照组(n=30例)和治疗组(n=30例)。对照组予西药依那普利叶酸片治疗,治疗组在对照组的基础上予联合加味黄连温胆汤。治疗6周后观察两组血压、Hcy、HOMA-IR和中医症状等治疗前后变化。结果治疗前后两组血压均明显下降(P<0.01),且治疗组下降明显优于对照组(P<0.05)。血压总有效率治疗组高于对照组(P<0.05)。两组治疗前后空腹血糖、空腹胰岛素、Hcy和IR均降低(P<0.05),且疗后治疗组降低明显优于对照组(P<0.05)。治疗前后两组中医症状积分皆有所下降(P<0.05),而疗后治疗组下降程度明显高于对照组(P<0.01)。中医症状疗效总有效率比较,治疗组高于对照组(P<0.05),具有明显统计学意义。结论加味黄连温胆汤可明显降低血压、Hcy和胰岛素抵抗,显著改善中医临床症状。
Objective To observe the clinical efficacy of Modified Huanglian Wendan Decoction(加味黄连温胆汤)in the treatment of blood pressure,Hcy and insulin resistance in H-type hypertensionandexplore its efficacy and safety.Methods A total of 60 patients with H-type hypertension in the outpatient department of cardiology of The First Affiliated Hospital of Heilongjiang University of Chinese Medicine were randomly divided into the control group(n=30)and the treatment group(n=30).The control group was treated withEnalapril Folic Acid Tabletsand the treatment group was treated with Modified Huanglian Wendan Decoction on the basis of the control group.Blood pressure,Hcy,HOMA-IR and TCM symptoms of the two groups were observed after 6 weeks of treatment.Results The blood pressure of both groups was decreased significantlyafter treatment(P<0.01),and the decrease in the treatment group was significantly better than that in the control group(P<0.05).The total effective rate of blood pressure in the treatment group was higher than that in the control group(P<0.05).Fasting glucose,fasting insulin,Hcy and insulin resistance were all decreasedafter treatment in both groups(P<0.05),and the reduction in the treatment group was significantly better than that in the control group(P<0.05).Before and after treatment,the TCM symptom scores of both groups were decreased(P<0.05),while the degree of decrease in the treatment group was significantly higher than that in the control group(P<0.01).The total effective rate of TCM symptoms was higher in the treatment group than that in the control group,with significant statistical significance(P<0.05).Conclusion Modified Huanglian Wendan Decoction can significantly reduce blood pressure,Hcy and insulin resistance,and significantly improve the clinical symptoms of TCM.
作者
李秀婷
刘莉
LI Xiuting;LIU Li(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)
出处
《辽宁中医杂志》
CAS
2021年第7期131-133,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81573935)
关键词
H型高血压
HCY
胰岛素抵抗
加味黄连温胆汤
H-type hypertension
Hcy
insulin resistance
Modified Huanglian Wendan Decoction(加味黄连温胆汤)
